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1例因腹膜播散和腹主动脉旁淋巴结转移导致乙状结肠癌伴肾积水患者对化疗有显著反应

[A case of sigmoid colon carcinoma accompanied with hydronephrosis caused by peritoneal dissemination and para-aortic lymph node metastases markedly responded to chemotherapy].

作者信息

Hasegawa Kumi, Matsumoto Rikio, Yamada Hirofumi, Kuroda Toru, Mamiya Yutaka, Kon Akira

机构信息

Department of Surgery, Sekishindo Hospital.

出版信息

Gan To Kagaku Ryoho. 2009 Nov;36(12):2213-6.

Abstract

The patient was a 64-year-old male diagnosed as advanced sigmoid colon cancer accompanied with hydronephrosis caused by peritoneal dissemination and para-aortic lymph node metastases. We performed transverse colostomy in the end of June 2008. Though he got renal failure, he was recovered by dialysis and diuretic. He received chemotherapy with LV+5-FU in the middle of August, continuously with bevacizumab (BV)+mFOLFOX6 in the end of October. In December, an elevated CEA marker was decreased after these treatments. Sigmoidectomy was done in the beginning of February 2009, dissemination disappeared completely. Histologically, most mucinous carcinoma cells disappeared or denatured, with viable tumor cells slightly remained.

摘要

该患者为64岁男性,被诊断为晚期乙状结肠癌,伴有腹膜播散和主动脉旁淋巴结转移引起的肾积水。我们于2008年6月底进行了横结肠造口术。尽管他出现了肾衰竭,但通过透析和利尿剂治疗后康复。他于8月中旬接受了LV + 5 - FU化疗,并于10月底持续接受贝伐单抗(BV)+ mFOLFOX6化疗。12月,这些治疗后升高的癌胚抗原(CEA)标志物有所下降。2009年2月初进行了乙状结肠切除术,播散完全消失。组织学检查显示,大多数黏液癌细胞消失或变性,仍有少量存活的肿瘤细胞。

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