强直性脊柱炎患者血浆和红细胞抗氧化状态的下降。
Decrease in antioxidant status of plasma and erythrocytes from patients with ankylosing spondylitis.
机构信息
Department and Clinic of Internal Diseases, Angiology and Physical Medicine, Medical University of Silesia, 15 Batorego Street, 41-902 Bytom, Poland.
出版信息
Clin Biochem. 2010 Apr;43(6):566-70. doi: 10.1016/j.clinbiochem.2009.12.019. Epub 2010 Jan 4.
OBJECTIVES
The aim of the study was to evaluate the antioxidant status in plasma and erythrocytes from patients with ankylosing spondylitis (AS).
METHODS
16 patients with AS and 16 healthy volunteers were involved in this study. Activities of antioxidant enzymes: superoxide dismutase (SOD) and its isoenzymes - (SOD-Mn) and (SOD-ZnCu), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione transferase (GST), as well as the total antioxidant status (TAS) and concentration of malondialdehyde (MDA) in plasma and/or erythrocytes, respectively were determined.
RESULTS
In patients with AS, a statistically significant decrease in plasma activity of SOD, SOD-CuZn and TAS, significant drop in activity of SOD, GPx, GST and GR in erythrocytes, as well as increased concentration of MDA in comparison with control group of healthy volunteers was observed.
CONCLUSION
Decrease in antioxidant status leading to generation of oxidative stress may play an important role in the pathogenesis of ankylosing spondylitis.
目的
本研究旨在评估强直性脊柱炎（AS）患者血浆和红细胞中的抗氧化状态。
方法
本研究纳入了 16 例 AS 患者和 16 名健康志愿者。分别测定了抗氧化酶活性：超氧化物歧化酶（SOD）及其同工酶（SOD-Mn 和 SOD-ZnCu）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）、谷胱甘肽还原酶（GR）和谷胱甘肽转移酶（GST），以及血浆和/或红细胞中的总抗氧化状态（TAS）和丙二醛（MDA）浓度。
结果
与健康志愿者对照组相比，AS 患者的血浆 SOD、SOD-CuZn 和 TAS 活性显著降低，红细胞 SOD、GPx、GST 和 GR 活性显著下降，MDA 浓度升高。
结论
导致氧化应激产生的抗氧化状态下降可能在强直性脊柱炎的发病机制中起重要作用。
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