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纳米技术的商业化。

Commercialization of nanotechnology.

机构信息

nanoTox Inc., Austin, TX, USA.

出版信息

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2009 Mar-Apr;1(2):189-202. doi: 10.1002/wnan.28.

Abstract

The emerging and potential commercial applications of nanotechnologies clearly have great potential to significantly advance and even potentially revolutionize various aspects of medical practice and medical product development. Nanotechnology is already touching upon many aspects of medicine, including drug delivery, diagnostic imaging, clinical diagnostics, nanomedicines, and the use of nanomaterials in medical devices. This technology is already having an impact; many products are on the market and a growing number is in the pipeline. Momentum is steadily building for the successful development of additional nanotech products to diagnose and treat disease; the most active areas of product development are drug delivery and in vivo imaging. Nanotechnology is also addressing many unmet needs in the pharmaceutical industry, including the reformulation of drugs to improve their bioavailability or toxicity profiles. The advancement of medical nanotechnology is expected to advance over at least three different generations or phases, beginning with the introduction of simple nanoparticulate and nanostructural improvements to current product and process types, then eventually moving on to nanoproducts and nanodevices that are limited only by the imagination and limits of the technology itself. This review looks at some recent developments in the commercialization of nanotechnology for various medical applications as well as general trends in the industry, and explores the nanotechnology industry that is involved in developing medical products and procedures with a view toward technology commercialization.

摘要

新兴的和潜在的商业应用纳米技术显然具有巨大的潜力,可显著推进甚至可能彻底改变医学实践和医疗产品开发的各个方面。纳米技术已经触及医学的许多方面,包括药物输送、诊断成像、临床诊断、纳米药物以及医疗器械中纳米材料的使用。这项技术已经产生了影响;许多产品已经上市,越来越多的产品正在研发中。为成功开发用于诊断和治疗疾病的额外纳米技术产品,正在稳步建立动力;产品开发最活跃的领域是药物输送和体内成像。纳米技术还解决了制药行业的许多未满足的需求,包括改进药物的配方以提高其生物利用度或毒性特征。预计医疗纳米技术的发展将至少经历三代或三个阶段,首先是对当前产品和工艺类型进行简单的纳米颗粒和纳米结构改进,然后最终发展到仅受想象和技术本身限制的纳米产品和纳米器件。这篇综述探讨了纳米技术在各种医疗应用中的商业化的一些最新进展以及该行业的一般趋势,并探讨了参与开发医疗产品和程序的纳米技术行业,以期实现技术商业化。

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