Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Adv Exp Med Biol. 2009;666:32-48. doi: 10.1007/978-1-4419-1601-3_3.
Complement activation is a crucial step in our innate immune defense against invading bacteria. Complement proteins can quickly recognize invading bacteria and subsequently label them for phagocytosis or kill them by direct lysis. In order to survive in the human host, bacterial pathogens have evolved a number of excreted and membrane-bound proteins that interfere with several steps of the complement cascade. In this chapter we summarize the most successful complement-modulating strategies by human bacterial pathogens.
补体激活是我们先天免疫防御入侵细菌的关键步骤。补体蛋白可以快速识别入侵的细菌，随后通过吞噬作用将其标记或直接溶解杀死。为了在人体宿主中存活，细菌病原体已经进化出许多分泌和膜结合蛋白，这些蛋白可以干扰补体级联反应的几个步骤。在本章中，我们总结了人类细菌病原体最成功的补体调节策略。
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