肾脏并发症：他汀类药物为何并非总能起效？ - Suppr

Kidney complications: why don't statins always work?

作者信息

Karumanchi S Ananth, Thadhani Ravi

机构信息

Vascular Biology, Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.

出版信息

Nat Med. 2010 Jan;16(1):38-40. doi: 10.1038/nm0110-38.

DOI:10.1038/nm0110-38

PMID:20057425

Abstract

摘要

相似文献

Kidney complications: why don't statins always work?

Nat Med. 2010 Jan;16(1):38-40. doi: 10.1038/nm0110-38.

Statin therapy: when to think twice.

J Fam Pract. 2013 Dec;62(12):726-32.

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Angiology. 2008 Apr-May;59(2 Suppl):58S-61S. doi: 10.1177/0003319708319643. Epub 2008 May 28.

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Expert Opin Pharmacother. 2012 Mar;13(4):457-60. doi: 10.1517/14656566.2012.661716. Epub 2012 Feb 15.

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JAMA Cardiol. 2021 Jul 1;6(7):741-742. doi: 10.1001/jamacardio.2021.1133.

Statins for heart failure: a potential for new treatment.

Cardiovasc Res. 2003 Nov 1;60(2):217-9. doi: 10.1016/j.cardiores.2003.09.006.

Cardiac effects of statins--advancements and open questions.

Cardiovasc Res. 2005 Jun 1;66(3):427-9. doi: 10.1016/j.cardiores.2005.03.021.

Statins and heart failure.

J Am Coll Cardiol. 2010 Apr 13;55(15):1644-5; author reply 1646. doi: 10.1016/j.jacc.2009.11.071.

引用本文的文献

Probiotics restore enteric HDL3 secretion and improve prognosis in patients with end-stage renal disease.

Imeta. 2025 Jul 1;4(4):e70062. doi: 10.1002/imt2.70062. eCollection 2025 Aug.

MicroRNA-142-3p improves vascular relaxation in uremia.

Atherosclerosis. 2019 Jan;280:28-36. doi: 10.1016/j.atherosclerosis.2018.11.024. Epub 2018 Nov 10.

Protein carbamylation is associated with heart failure and mortality in diabetic patients with end-stage renal disease.

Kidney Int. 2015 Jun;87(6):1201-8. doi: 10.1038/ki.2014.429. Epub 2015 Feb 11.

The authors reply.

Kidney Int. 2014 Aug;86(2):446. doi: 10.1038/ki.2014.137.

Carbamylation of serum albumin as a risk factor for mortality in patients with kidney failure.

Sci Transl Med. 2013 Mar 6;5(175):175ra29. doi: 10.1126/scitranslmed.3005218.

Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the Atherosclerosis Risk in Communities Study.

Circulation. 2011 Apr 5;123(13):1367-76. doi: 10.1161/CIRCULATIONAHA.110.005264. Epub 2011 Mar 21.

本文引用的文献

Is calcitriol life-protective for patients with chronic kidney disease?

J Am Soc Nephrol. 2009 Nov;20(11):2285-90. doi: 10.1681/ASN.2009050494. Epub 2009 Aug 13.

Rosuvastatin and cardiovascular events in patients undergoing hemodialysis.

N Engl J Med. 2009 Apr 2;360(14):1395-407. doi: 10.1056/NEJMoa0810177. Epub 2009 Mar 30.

Uremic cardiac hypertrophy is reversed by rapamycin but not by lowering of blood pressure.

Kidney Int. 2009 Apr;75(8):800-8. doi: 10.1038/ki.2008.690. Epub 2009 Jan 21.

Low-dose growth hormone is cardioprotective in uremia.

J Am Soc Nephrol. 2008 Sep;19(9):1774-83. doi: 10.1681/ASN.2007121386. Epub 2008 Jul 23.

Emerging biomarkers for evaluating cardiovascular risk in the chronic kidney disease patient: how do new pieces fit into the uremic puzzle?

Clin J Am Soc Nephrol. 2008 Mar;3(2):505-21. doi: 10.2215/CJN.03670807. Epub 2008 Jan 9.

Protein carbamylation links inflammation, smoking, uremia and atherogenesis.

Nat Med. 2007 Oct;13(10):1176-84. doi: 10.1038/nm1637. Epub 2007 Sep 9.

Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy.

Hypertension. 2006 Mar;47(3):488-95. doi: 10.1161/01.HYP.0000202594.82271.92. Epub 2006 Jan 30.

Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis.

N Engl J Med. 2005 Jul 21;353(3):238-48. doi: 10.1056/NEJMoa043545.

Association between cholesterol level and mortality in dialysis patients: role of inflammation and malnutrition.

JAMA. 2004 Jan 28;291(4):451-9. doi: 10.1001/jama.291.4.451.

Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention.

Circulation. 2003 Oct 28;108(17):2154-69. doi: 10.1161/01.CIR.0000095676.90936.80.

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相似文献

Kidney complications: why don't statins always work?

Nat Med. 2010 Jan;16(1):38-40. doi: 10.1038/nm0110-38.

Statin therapy: when to think twice.

J Fam Pract. 2013 Dec;62(12):726-32.

Statins and heart failure.

Angiology. 2008 Apr-May;59(2 Suppl):58S-61S. doi: 10.1177/0003319708319643. Epub 2008 May 28.

Stage of chronic kidney disease and severity of coronary heart disease manifestation.

Expert Opin Pharmacother. 2012 Mar;13(4):457-60. doi: 10.1517/14656566.2012.661716. Epub 2012 Feb 15.

Statins: some women don't get the benefits.

Consum Rep. 2010 Aug;75(8):12.

The statin wars.

Lancet. 2003 Nov 29;362(9398):1854; discussion 1856. doi: 10.1016/S0140-6736(03)14908-2.

Could Flozins Be the Statins for Risk-Based Primary Prevention of Heart Failure?

JAMA Cardiol. 2021 Jul 1;6(7):741-742. doi: 10.1001/jamacardio.2021.1133.

Statins for heart failure: a potential for new treatment.

Cardiovasc Res. 2003 Nov 1;60(2):217-9. doi: 10.1016/j.cardiores.2003.09.006.

Cardiac effects of statins--advancements and open questions.

Cardiovasc Res. 2005 Jun 1;66(3):427-9. doi: 10.1016/j.cardiores.2005.03.021.

Statins and heart failure.

J Am Coll Cardiol. 2010 Apr 13;55(15):1644-5; author reply 1646. doi: 10.1016/j.jacc.2009.11.071.

引用本文的文献

Probiotics restore enteric HDL3 secretion and improve prognosis in patients with end-stage renal disease.

Imeta. 2025 Jul 1;4(4):e70062. doi: 10.1002/imt2.70062. eCollection 2025 Aug.

MicroRNA-142-3p improves vascular relaxation in uremia.

Atherosclerosis. 2019 Jan;280:28-36. doi: 10.1016/j.atherosclerosis.2018.11.024. Epub 2018 Nov 10.

Protein carbamylation is associated with heart failure and mortality in diabetic patients with end-stage renal disease.

Kidney Int. 2015 Jun;87(6):1201-8. doi: 10.1038/ki.2014.429. Epub 2015 Feb 11.

The authors reply.

Kidney Int. 2014 Aug;86(2):446. doi: 10.1038/ki.2014.137.

Carbamylation of serum albumin as a risk factor for mortality in patients with kidney failure.

Sci Transl Med. 2013 Mar 6;5(175):175ra29. doi: 10.1126/scitranslmed.3005218.

Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the Atherosclerosis Risk in Communities Study.

Circulation. 2011 Apr 5;123(13):1367-76. doi: 10.1161/CIRCULATIONAHA.110.005264. Epub 2011 Mar 21.

本文引用的文献

Is calcitriol life-protective for patients with chronic kidney disease?

J Am Soc Nephrol. 2009 Nov;20(11):2285-90. doi: 10.1681/ASN.2009050494. Epub 2009 Aug 13.

Rosuvastatin and cardiovascular events in patients undergoing hemodialysis.

N Engl J Med. 2009 Apr 2;360(14):1395-407. doi: 10.1056/NEJMoa0810177. Epub 2009 Mar 30.

Uremic cardiac hypertrophy is reversed by rapamycin but not by lowering of blood pressure.

Kidney Int. 2009 Apr;75(8):800-8. doi: 10.1038/ki.2008.690. Epub 2009 Jan 21.

Low-dose growth hormone is cardioprotective in uremia.

J Am Soc Nephrol. 2008 Sep;19(9):1774-83. doi: 10.1681/ASN.2007121386. Epub 2008 Jul 23.

Emerging biomarkers for evaluating cardiovascular risk in the chronic kidney disease patient: how do new pieces fit into the uremic puzzle?

Clin J Am Soc Nephrol. 2008 Mar;3(2):505-21. doi: 10.2215/CJN.03670807. Epub 2008 Jan 9.

Protein carbamylation links inflammation, smoking, uremia and atherogenesis.

Nat Med. 2007 Oct;13(10):1176-84. doi: 10.1038/nm1637. Epub 2007 Sep 9.

Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy.

Hypertension. 2006 Mar;47(3):488-95. doi: 10.1161/01.HYP.0000202594.82271.92. Epub 2006 Jan 30.

Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis.

N Engl J Med. 2005 Jul 21;353(3):238-48. doi: 10.1056/NEJMoa043545.

Association between cholesterol level and mortality in dialysis patients: role of inflammation and malnutrition.

JAMA. 2004 Jan 28;291(4):451-9. doi: 10.1001/jama.291.4.451.

Circulation. 2003 Oct 28;108(17):2154-69. doi: 10.1161/01.CIR.0000095676.90936.80.

Kidney complications: why don't statins always work?

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