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[关于真性红细胞增多症红细胞骨髓幼红细胞岛对促红细胞生成素的敏感性]

[About sensitive of erythroblastic islands bone marrow of polycythemic reds to erythropoietin].

作者信息

Zakharov Iu M, Feklicheva I V

出版信息

Ross Fiziol Zh Im I M Sechenova. 2009 Nov;95(11):1198-206.

Abstract

The sensibility to erythropoietin oferythroblastic islands of bone marrow which were made in different terms after the creation of transfusion polycytemia is researched. It turned out that the central macrophags of involuting erythroblastic islands are more sensible to erythropoietin than residual macrophags of bone marrow. The capability of residual macrophags to form erythroblastic islands is opened to the bigger inhibitory influence during the development of transfusion polycytemia than to the central macrjphags of involuting erythroblastic islands.

摘要

研究了在输血性红细胞增多症形成后不同时期所制备的骨髓幼红细胞岛对促红细胞生成素的敏感性。结果表明,退化幼红细胞岛的中央巨噬细胞比骨髓残余巨噬细胞对促红细胞生成素更敏感。在输血性红细胞增多症发展过程中,残余巨噬细胞形成幼红细胞岛的能力比退化幼红细胞岛的中央巨噬细胞受到更大的抑制影响。

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