STAT3 多态性与特发性复发性流产有关。
STAT3 polymorphisms linked with idiopathic recurrent miscarriages.
机构信息
Faculty of Medicine, Université St Joseph, Beirut, Lebanon.
出版信息
Am J Reprod Immunol. 2010 Jan;63(1):22-7. doi: 10.1111/j.1600-0897.2009.00765.x.
PROBLEM
We investigated the association of signal transducers and activators of transcription (STAT)3 gene variants with idiopathic recurrent miscarriage (RM).
METHOD OF STUDY
A case-control study involving 189 RM patients and 244 control women was carried out. STAT3 (rs1053004 and rs1023023) genotyping was performed by allelic discrimination/real-time PCR method.
RESULTS
STAT3 rs1053004 C allele [OR (95% CI) = 1.60 (1.22-2.10)] and C/C genotype [OR (95% CI) = 3.42 (1.70-6.92)] were positively associated with RM. Two-locus (rs1053004/rs1053023) haplotype analysis revealed increased frequency of CG and CA haplotypes in RM patients, of which only CA haplotype (Pc = 0.020) remained positively associated with RM after applying the Bonferroni correction. This was confirmed by multivariate regression analysis (OR = 1.70; 95% CI = 1.17-2.46) after adjusting for a number of covariates.
CONCLUSION
STAT3 rs1053004 variant is significantly associated with idiopathic RM. Replication studies on other racial groups and other STAT3 gene variants are warranted.
问题
我们研究了信号转导和转录激活因子（STAT）3 基因变异与特发性复发性流产（RM）的关联。
方法
进行了一项病例对照研究，纳入了 189 名 RM 患者和 244 名对照女性。通过等位基因鉴别/实时 PCR 方法对 STAT3（rs1053004 和 rs1023023）进行基因分型。
结果
STAT3 rs1053004 C 等位基因[比值比（95%可信区间）= 1.60（1.22-2.10）]和 C/C 基因型[比值比（95%可信区间）= 3.42（1.70-6.92）]与 RM 呈正相关。双位点（rs1053004/rs1053023）单体型分析显示 RM 患者 CG 和 CA 单体型频率增加，其中仅 CA 单体型（Pc = 0.020）在应用 Bonferroni 校正后仍与 RM 呈正相关。这在调整了多个协变量后，通过多变量回归分析（OR = 1.70；95%CI = 1.17-2.46）得到了证实。
结论
STAT3 rs1053004 变异与特发性 RM 显著相关。有必要在其他种族群体和其他 STAT3 基因变异中进行复制研究。
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