T 细胞受体交叉反应的多种机制。

The multiple mechanisms of T cell receptor cross-reactivity.

机构信息

Center for Advanced Research in Biotechnology, WM Keck Laboratory for Structural Biology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA.

出版信息

Immunity. 2009 Dec 18;31(6):849-51. doi: 10.1016/j.immuni.2009.12.002.

DOI:10.1016/j.immuni.2009.12.002

PMID:20064442

Abstract

The ability of a single T cell to recognize the diverse peptides it encounters is based on T cell receptor crossreactivity. In this issue of Immunity, Macdonald et al. (2009) and Borbulevych et al. (2009) provide new insights into the structural principles underlying this fundamental property of T cells.

摘要

单个 T 细胞识别其所遇到的各种肽的能力基于 T 细胞受体的交叉反应性。在本期《免疫》杂志中，Macdonald 等人（2009）和 Borbulevych 等人（2009）提供了关于 T 细胞这一基本特性的结构原理的新见解。