转录因子NFIC在成牙本质细胞基因表达中的作用。
Role of the transcription factor NFIC in odontoblast gene expression.
作者信息
Kim Mi Young, Reyna Julia, Chen Li-Sha, Zeichner-David Maggie
机构信息
University of Southern California, School of Dentistry, Los Angeles, USA.
出版信息
J Calif Dent Assoc. 2009 Dec;37(12):875-81.
The transcription factor NFI-C is essential for root development. Mice lacking NFI-C develop abnormal roots and lose their teeth, resembling radicular dentin dysplasia I in humans. The purpose of this study was to understand the role of NFI-C in dentinogenesis. The authors found statistically significant increases in the expression of several mRNAs in cells lacking NFI-C, suggesting that these molecules might interfere with odontoblast cell migration and differentiation, and consequently with root development.
转录因子NFI-C对牙根发育至关重要。缺乏NFI-C的小鼠会出现牙根异常并掉牙，类似于人类的I型牙根牙本质发育异常。本研究的目的是了解NFI-C在牙本质形成中的作用。作者发现，在缺乏NFI-C的细胞中，几种mRNA的表达有统计学意义的增加，这表明这些分子可能会干扰成牙本质细胞的迁移和分化，进而影响牙根发育。
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