Department of Public Health, University of Helsinki, PO Box 14, 00014 Helsinki, Finland.
Alcohol Alcohol. 2010 Mar-Apr;45(2):173-9. doi: 10.1093/alcalc/agp090. Epub 2010 Jan 12.
The study aimed to determine whether alcohol use during late adolescence contributes to the weight gain from adolescence to young adulthood or risk of obesity or waist circumference at young adulthood.
A population-based, longitudinal study of 5563 Finnish twins born in 1975-1979 and surveyed at ages 16 (T1), 17 (T2), 18 (T3) and 23-27 (T4) years. Drinking habits, height and weight were self-reported at T1, T2, T3 and T4; waist circumference was self-measured at T4. As potential confounders, we used smoking, diet, physical activity, place of residence, socio-economic status and parents' body mass index (BMI).
Compared to the reference group (drinking once to twice per month), the BMI increase from T3 to T4 was less among abstaining men (-0.62 kg/m(2), (95% CI -1.04, -0.20)) and among women in those drinking less than monthly (-0.38 kg/m(2), (-0.71, -0.04)). In women, at least weekly drinking was associated with larger waist circumference (Beta 1.55 cm, (0.48, 2.61)), but this became statistically non-significant after adjusting for potential confounders. In a multilevel model for change, drinking frequency was not associated with weight change in women; in men, a negative association was seen, but it was statistically non-significant after adjusting for potential confounders.
These results from a population-based study with a large set of confounding variables suggest that alcohol use during adolescence has at most a minor effect on weight gain or development of abdominal obesity from adolescence to young adulthood.
本研究旨在确定青少年晚期饮酒是否会导致青少年期到成年早期的体重增加,或者是否会增加成年早期肥胖或腰围的风险。
这是一项基于人群的纵向研究,共纳入了 5563 名芬兰双胞胎,他们于 1975-1979 年出生,在 16 岁(T1)、17 岁(T2)、18 岁(T3)和 23-27 岁(T4)时接受调查。饮酒习惯、身高和体重在 T1、T2、T3 和 T4 时均由自我报告;腰围在 T4 时由自我测量。吸烟、饮食、体育活动、居住地、社会经济地位和父母体重指数(BMI)等因素被用作潜在的混杂因素。
与参考组(每月饮酒 1-2 次)相比,从不饮酒的男性(-0.62kg/m2,95%CI-1.04,-0.20)和每月饮酒次数少于一次的女性(-0.38kg/m2,-0.71,-0.04)从 T3 到 T4 的 BMI 增加幅度较小。在女性中,至少每周饮酒与较大的腰围相关(Beta1.55cm,(0.48,2.61)),但在调整潜在混杂因素后,这一关联不再具有统计学意义。在女性体重变化的多层次模型中,饮酒频率与体重变化无关;而在男性中,虽然存在负相关,但在调整潜在混杂因素后,这一关联不再具有统计学意义。
这项基于人群的研究纳入了大量混杂变量,结果表明,青少年时期的饮酒行为对青少年期到成年早期的体重增加或腹型肥胖的发展影响很小。