Psidials A-C，三种来自番石榴叶的罕见倍半萜类化合物
Psidials A-C, three unusual meroterpenoids from the leaves of Psidium guajava L.
机构信息
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing 100050, People's Republic of China.
出版信息
Org Lett. 2010 Feb 19;12(4):656-9. doi: 10.1021/ol9024869.
Three novel sesquiterpenoid-based meroterpenoids of psidials A-C (1-3) have been isolated from the leaves of Psidium guajava L. Their complete structures were elucidated by spectral and chemical methods, and that of 1 was confirmed by single-crystal X-ray diffraction analysis. Psidial B (2) and C (3) represented the new skeleton of the 3,5-diformylbenzyl phloroglucinol-coupled sesquiterpenoid. A possible biosynthetic pathway for 2-3 was postulated. 2-3 showed activity to enzyme PTP1B in 10 microM.
从番石榴（Psidium guajava L.）叶中分离得到三个新型倍半萜基混合二萜类化合物 psidials A-C（1-3）。通过光谱和化学方法阐明了它们的完整结构，并且通过单晶 X 射线衍射分析确定了 1 的结构。Psidial B（2）和 C（3）代表了 3,5-二醛基苄基间苯三酚偶联倍半萜的新骨架。推测了 2-3 的可能生物合成途径。2-3 在 10 μM 时对 PTP1B 酶表现出活性。
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