苦参中的生物碱。

Alkaloids from Sophora flavescens Aition.

机构信息

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.

出版信息

Fitoterapia. 2010 Sep;81(6):524-7. doi: 10.1016/j.fitote.2010.01.008. Epub 2010 Jan 15.

DOI:10.1016/j.fitote.2010.01.008

PMID:20079811

Abstract

Although the quinolizidine alkaloids and flavonoids, the main active components of the traditional Chinese medicine Sophora flavescens, have been largely investigated, a new matrine alkaloid derivative 9alpha-hydroxy-7,11-dehydromatrine (1) and a rare 1,4-diazaindan-type alkaloid flavascensine (17), together with 15 known alkaloids, were isolated from S. flavescens. The structures were established on the basis of spectroscopic techniques.

摘要

尽管传统中药苦参中的主要活性成分喹诺里西啶生物碱和黄酮类化合物已经得到了广泛的研究，但从苦参中分离出了一种新的苦参碱生物碱衍生物 9alpha-羟基-7,11-脱水苦参碱 (1) 和一种罕见的 1,4-二氮杂吲哚型生物碱 flavascensine (17)，以及 15 种已知的生物碱。这些结构是基于光谱技术确定的。