Department of Laboratory Animal Medicine, College of Veterinary Medicine and KRF Zoonotic Disease Priority Research Institute, Seoul National University, Seoul, Republic of Korea.
Vet Pathol. 2010 Jan;47(1):137-9. doi: 10.1177/0300985809353311.
Spontaneous basal cell carcinoma (BCC) is very rare in rats, with an incidence rate of only 0.14% reported in aged animals. A spontaneous BCC occurred in a 7-week-old Sprague-Dawley rat housed in a specific-pathogen-free animal facility. The tumor was a single, well-delineated reddish-brown subcutaneous mass measuring 2 x 2 cm and located in the left inguinal region. Microscopically, the tumor consisted of basaloid cells in lobular and cribriform growth patterns and with a high mitotic rate. Immunohistochemically, cytokeratin 14 (an indicator for basal keratinocytes of the epidermis) showed strong reactions throughout the whole tumor, and cytokeratin 18 showed weak but positive reaction in the majority of nested tumor cells. To the authors' knowledge, this is the first report of spontaneous BCC occurrence in young Sprague-Dawley rats.
自发性基底细胞癌（BCC）在大鼠中非常罕见，据报道，老年动物的发病率仅为 0.14%。一只 7 周大的 Sprague-Dawley 大鼠在无特定病原体的动物设施中发生自发性 BCC。肿瘤为单个、界限清楚的红棕色皮下肿块，大小为 2 x 2 厘米，位于左侧腹股沟区域。显微镜下，肿瘤由小叶状和筛状生长模式的基底样细胞组成，具有较高的有丝分裂率。免疫组织化学染色显示，角蛋白 14（表皮基底角蛋白细胞的标志物）在整个肿瘤中均呈强烈反应，角蛋白 18 在大多数巢状肿瘤细胞中呈弱阳性反应。据作者所知，这是首例年轻 Sprague-Dawley 大鼠自发性 BCC 发生的报告。
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