Silver J M, Rawlings C E, Rossitch E, Zeidman S M, Friedman A H
Division of Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710.
Surg Neurol. 1991 Apr;35(4):261-6. doi: 10.1016/0090-3019(91)90002-q.
Gangliogliomas are uncommon tumors of mixed neoplastic glial and neuronal elements. Because of their low incidence, few large series exist that fully describe the clinical characteristics of patients afflicted with this tumor. We have reviewed the medical records of 20 patients at Duke University Medical Center with histologically proven gangliogliomas. These patients typically presented within the first three decades of life and their most common presenting symptom was seizures. Therapies included surgical resection, either partial or total, radiation therapy, and/or chemotherapy. Long-term follow-up was achieved by chart review and by telephone interview. Patients who underwent gross total resection alone seemed to fare the best when comparing all treatment groups, and we therefore recommend this as the main form of treatment.
神经节胶质瘤是一种由肿瘤性神经胶质和神经元成分混合组成的罕见肿瘤。由于其发病率低，很少有大型系列研究能全面描述罹患这种肿瘤患者的临床特征。我们回顾了杜克大学医学中心20例经组织学证实为神经节胶质瘤患者的病历。这些患者通常在生命的头三十年发病，最常见的首发症状是癫痫发作。治疗方法包括部分或全部手术切除、放射治疗和/或化疗。通过查阅病历和电话随访实现了长期随访。在比较所有治疗组时，仅接受全切除的患者预后似乎最佳，因此我们建议将其作为主要治疗方式。
