Ito Kazushige, Ogata Takashi, Katayanagi So, Nomura Tomohisa, Ishizaki Tetsuo, Yasuda Yoshihiro, Sonoda Ichiro, Suzuki Yoshiaki, Sumi Tetsuo, Tsuchida Akihiko, Aoki Tatsuya, Shimazu Motohide
Department of Digestive Tract Surgery, Tokyo Medical University Hachioji Medical Center, Japan.
Gan To Kagaku Ryoho. 2010 Jan;37(1):135-8.
S-1 is a key drug for advanced, recurrent gastric cancer. It is difficult to administer S-1 for inoperable gastric cancer with stenosis. We report that a simple suspension method allows administration of S-1 for improved quality of life. The patient was a 65-year-old woman. She consulted a doctor regarding her poor food intake, and had a medical examination with chest-abdominal CT and gastrofiberscopy. She was diagnosed as type 4 gastric cancer with esophageal invasion. It was difficult for her to drink a cup of water due to the stenosis, but we could insert a 6 Fr-Elemental Diet (ED) tube into her stomach. S-1 was dissolved by the simple suspension method. She received combination chemotherapy of S-1 100mg/body (day 1-21) and CDDP 80 mg/body (day 8). After two courses, her intake was much improved; she was able to eat rice porridge and was discharged with improved quality of life. S-1 suspension with ED tube was effective for advanced gastric cancer with stenosis.