Liu Yan, Wen Feng, Li Jiaqing, Zuo Chengguo, Li Meng
Department of Ophthalmology, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai 200031, China.
Doc Ophthalmol. 2009 Dec;119(3):163-9. doi: 10.1007/s10633-009-9189-2.
To compare the differences in color Doppler imaging (CDI) and pattern visual evoked potential (P-VEP) examinations between normal tension glaucoma (NTG) and hypertension primary open angle glaucoma (HTG) patients, and investigate the relation between flow velocities measured by CDI and P-VEP examination in NTG and HTG patients. Sixty NTG patients, 66 HTG patients and 44 control subjects underwent CDI evaluation of the ophthalmic artery (OA), short posterior ciliary artery (SPCA) and central retinal arteries (CRA). The peak systolic velocities (PSV) and end-diastolic velocities (EDV) and resistive index (RI) of all retrobulbar vessels were measured. The latency and amplitude of P100 in P-VEP were recorded from the three groups. The differences of CDI and P-VEP parameters among NTG group, HTG group and control group were compared by one-way analysis of variance. The correlations between CDI parameters and visual field indices, P-VEP and visual field indices, P-VEP and CDI parameters in NTG and HTG patients were evaluated by Pearson's correlation analysis. NTG and HTG patients had the lower EDV and higher RI in the OA, CRA and SPCA comparing with that of control subjects. NTG and HTG patients also had lower PSV in OA and CRA comparing with that of control subjects. There was no significant difference in the blood flow velocities and RI of all retrobulbar vessels between NTG and HTG patients. The latency of P100 in VEP delayed and the amplitude of P100 decreased in the NTG and HTG patients comparing with that of the control group. There was no significant difference in the latency and amplitude of P100 between the NTG and HTG patients. The RI of OA and SPCA were negatively correlated with the mean deviation (MD) values in the NTG and HTG patients. The RI of OA was positively correlated with the PSD value in the NTG and HTG patients. The MD values in the NTG and HTG patients were negatively correlated with the latency time of P100. The RI of OA was positively correlated with the latency time of P100 in NTG and HTG patients. The RI of OA was negatively correlated with the amplitude of P100 in HTG patients. No significant difference was found in the parameters of CDI and P-VEP between NTG and HTG patients. The certain parameters of CDI were correlated with P-VEP parameters in NTG and HTG patients.
比较正常眼压性青光眼（NTG）和高血压原发性开角型青光眼（HTG）患者的彩色多普勒成像（CDI）和图形视觉诱发电位（P-VEP）检查结果的差异，并探讨NTG和HTG患者中CDI测量的血流速度与P-VEP检查之间的关系。60例NTG患者、66例HTG患者和44例对照者接受了眼动脉（OA）、睫状后短动脉（SPCA）和视网膜中央动脉（CRA）的CDI评估。测量了所有球后血管的收缩期峰值速度（PSV）、舒张末期速度（EDV）和阻力指数（RI）。记录了三组患者P-VEP中P100的潜伏期和波幅。采用单因素方差分析比较NTG组、HTG组和对照组之间CDI和P-VEP参数的差异。通过Pearson相关分析评估NTG和HTG患者中CDI参数与视野指数、P-VEP与视野指数、P-VEP与CDI参数之间的相关性。与对照组相比，NTG和HTG患者的OA、CRA和SPCA的EDV较低，RI较高。与对照组相比，NTG和HTG患者的OA和CRA的PSV也较低。NTG和HTG患者之间所有球后血管的血流速度和RI无显著差异。与对照组相比，NTG和HTG患者VEP中P100的潜伏期延长，P100波幅降低。NTG和HTG患者之间P100的潜伏期和波幅无显著差异。NTG和HTG患者中OA和SPCA的RI与平均偏差（MD）值呈负相关。NTG和HTG患者中OA的RI与PSD值呈正相关。NTG和HTG患者的MD值与P100的潜伏期呈负相关。NTG和HTG患者中OA的RI与P100的潜伏期呈正相关。HTG患者中OA的RI与P100的波幅呈负相关。NTG和HTG患者之间CDI和P-VEP参数无显著差异。NTG和HTG患者中CDI的某些参数与P-VEP参数相关。
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