凋亡基因 BCL2L13、Livin 和 CASP8AP2 在儿童急性淋巴细胞白血病中的表达及预后意义。
Expression and prognostic significance of the apoptotic genes BCL2L13, Livin, and CASP8AP2 in childhood acute lymphoblastic leukemia.
机构信息
Department of Laboratory Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
出版信息
Leuk Res. 2010 Jan;34(1):18-23. doi: 10.1016/j.leukres.2009.07.023.
Improved treatment of childhood acute lymphoblastic leukemia (ALL) depends on the identification of new molecular markers that are able to predict treatment response and clinical outcome. The development of impaired apoptosis in leukemic cells is one factor that may influence their response to treatment. We investigated the expression of three apoptosis related genes, BCL2L13, CASP8AP2, and Livin, as well as their prognostic significance, in a retrospective study of 90 pediatric ALL patients diagnosed between 1996 and 2007 in Taiwan. Univariant analysis revealed that high expression of BCL2L13 was associated with inferior event-free survival and overall survival (p<0.001 and 0.005, respectively). Multivariate analysis for EFS and OS demonstrated that high expression of BCL2L13 was an independent prognostic factor for childhood ALL in this ethnic group.
改善儿童急性淋巴细胞白血病（ALL）的治疗取决于能否确定新的分子标志物，这些标志物能够预测治疗反应和临床结果。白血病细胞中凋亡受损是影响其对治疗反应的一个因素。我们研究了在 1996 年至 2007 年期间在台湾诊断的 90 例儿科 ALL 患者的回顾性研究中，三种与凋亡相关的基因（BCL2L13、CASP8AP2 和 Livin）的表达及其预后意义。单变量分析显示，BCL2L13 高表达与无事件生存和总生存不良相关（p<0.001 和 0.005）。EFS 和 OS 的多变量分析表明，BCL2L13 高表达是该人群儿童 ALL 的独立预后因素。
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