人乳头瘤病毒（HPV）在头颈部：文献综述。
Human Papilloma Virus (HPV) in head and neck region: review of literature.
机构信息
Department of Otolaryngology HN Surgery, University of Pavia, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy.
出版信息
Acta Otorhinolaryngol Ital. 2009 Jun;29(3):119-26.
Abstract
The evidence that human papillomavirus infection is related to head and neck squamous cell carcinoma is supported by molecular and epidemiological data. The definition of a distinct subset of head and neck squamous cell carcinoma, independent of the traditional risk factors and with different clinical presentation and outcome, has led to increasing interest in human papillomavirus infection. This review summarizes current knowledge regarding human papillomavirus biology, oncogenic mechanisms, risk factors for transmission, clinical significance and prophylactic strategies.
摘要
人乳头瘤病毒感染与头颈部鳞状细胞癌的关系的证据得到了分子和流行病学数据的支持。定义了一个独特的头颈部鳞状细胞癌亚组，与传统的危险因素无关，具有不同的临床表现和结局，这导致了人们对头乳头瘤病毒感染越来越感兴趣。本文综述了人乳头瘤病毒生物学、致癌机制、传播危险因素、临床意义和预防策略的最新知识。
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