Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Outram Road, Singapore, Singapore.
J Headache Pain. 2010 Apr;11(2):175-8. doi: 10.1007/s10194-010-0193-4. Epub 2010 Feb 9.
Topiramate is known to be efficacious in migraine prophylaxis, but its optimal dose has not been systematically studied in the Asian population. Here, we show that a fixed low dose of topiramate 25 mg/day is efficacious in migraine prophylaxis and also attest to advantages in terms of medication cost savings and more favourable side effect profile.
托吡酯在偏头痛预防中已被证实有效，但在亚洲人群中尚未对其最佳剂量进行系统研究。在此，我们表明，托吡酯固定低剂量 25 毫克/天对偏头痛预防有效，而且在药物成本节约和更有利的副作用方面也具有优势。
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