Neonatal Unit, Christchurch Women's Hospital, Christchurch, New Zealand.
Acta Paediatr. 2010 Jul;99(7):1104-7. doi: 10.1111/j.1651-2227.2010.01717.x. Epub 2010 Feb 11.
A case of extensive deep venous thrombosis in a four a day old infant was presented. Unusually this patient was shown to be heterozygous for three thrombophilia genes; Factor V Leiden, prothrombin and antithrombin gene mutations, the latter being novel.
There are no randomized controlled trials to guide management in deep venous thrombosis in the newborn but knowledge of the prothrombotic risk factors may help direct treatment.
我们报告了一例每天服用四次药物的四天大婴儿发生广泛深静脉血栓形成的病例。不同寻常的是,该患者被证实携带三种血栓形成倾向基因,包括因子 V 莱顿、凝血酶原和抗凝血酶基因突变,其中抗凝血酶基因的突变是新发现的。
目前没有针对新生儿深静脉血栓形成的随机对照试验来指导管理,但对血栓形成危险因素的了解可能有助于指导治疗。