Department of Psychology, Stanford University, Stanford, CA 94305, USA.
Neuron. 2010 Feb 11;65(3):298-308. doi: 10.1016/j.neuron.2009.12.022.
High-resolution functional MRI (hr-fMRI) affords unique leverage on the functional properties of human medial temporal lobe (MTL) substructures. We review initial hr-fMRI efforts to delineate (1) encoding and retrieval processes within the hippocampal circuit, (2) hippocampal subfield contributions to pattern separation and pattern completion, and (3) the representational capabilities of distinct MTL subregions. Extant data reveal functional heterogeneity within human MTL and highlight the promise of hr-fMRI for bridging human, animal, and computational approaches to understanding MTL function.
高分辨率功能磁共振成像(hr-fMRI)为研究人类内侧颞叶(MTL)亚结构的功能特性提供了独特的优势。我们回顾了最初使用 hr-fMRI 来描绘(1)海马回路中的编码和检索过程,(2)海马亚区对模式分离和模式完成的贡献,以及(3)不同 MTL 亚区的表示能力。现有的数据揭示了人类 MTL 中的功能异质性,并强调了 hr-fMRI 在连接人类、动物和计算方法以理解 MTL 功能方面的潜力。