取代基常数与吡啶鎓 N - 甲基化学位移之间具有良好的相关性。
Excellent correlation between substituent constants and pyridinium N-methyl chemical shifts.
作者信息
Huang Sha, Wong Jesse C S, Leung Adam K C, Chan Yee Man, Wong Lili, Fernendez Myrien R, Miller Amanda K, Wu Weiming
机构信息
Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA 94132.
出版信息
Tetrahedron Lett. 2009 Sep 2;50(35):5018-5020. doi: 10.1016/j.tetlet.2009.06.081.
Abstract
Substituents on the pyridinium ring of N-methylpyridinium derivatives, especially those on the 2- or 4-positions, have a large effect on the (1)H and (13)C NMR chemical shifts of the N-methyl group. Reasonable correlations between the chemical shift changes and the resonance substituent constants are observed. The dual substituent parameter approach provides an excellent correlation when a combination of polar and resonance substituent constants is employed.
摘要
N-甲基吡啶鎓衍生物吡啶鎓环上的取代基，尤其是2-位或4-位上的取代基，对N-甲基的(1)H和(13)C NMR化学位移有很大影响。观察到化学位移变化与共振取代基常数之间存在合理的相关性。当采用极性取代基常数和共振取代基常数的组合时，双取代基参数方法能提供极佳的相关性。
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