高非对映选择性吲哚与 N-叔丁基亚磺酰亚胺酯的 Friedel-Crafts 反应：一种高效实用的方法，用于获得对映体富集的 α-(3-吲哚基)甘氨酸。
Highly diastereoselective Friedel-Crafts reaction of indoles with an N-tert-butanesulfinylimino ester: an efficient and practical approach to enantiomerically enriched alpha-(3-indolyl)glycines.
机构信息
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, P. R. China.
出版信息
Chem Commun (Camb). 2010 Mar 7;46(9):1550-2. doi: 10.1039/b914687c. Epub 2010 Jan 27.
DOI:10.1039/b914687c
PMID:20162178
Abstract
An efficient, mild and general method for the preparation of highly enantiomerically enriched alpha-(3-indolyl)glycines by the transition-metal-based Lewis acid-catalyzed diastereoselective Friedel-Crafts reaction of indoles with an N-tert-butanesulfinylimino ester has been developed.
摘要
一种高效、温和且通用的方法，通过过渡金属基路易斯酸催化吲哚与 N-叔丁基亚磺酰亚胺酯的非对映选择性 Friedel-Crafts 反应，制备高度对映体富集的α-(3-吲哚基)甘氨酸。
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