[P53、COX2和CD44V6在伴有或不伴有淋巴管间隙浸润的早期宫颈鳞状细胞癌中的表达及其与预后的关系]

[Expression of P53, COX2 and CD44V6 in early-stage squamous carcinoma of cervix with lymph vascular space invasion positive and negative and its relationship with prognosis].

作者信息

Zhang Rong, Song Yan, Gao Wei-jiao, Zhang Xun, Zuo Jing, Lei Cheng-zhi, Wang Ye

机构信息

Department of Gynecological Oncology, Chinese Academy of Medical Sciences, Beijing 100021, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2009 Dec 22;89(47):3341-5.

PMID:20193563

Abstract

OBJECTIVE

To investigate the relationship between lymph vascular space invasion (LVSI) and various clinicopathologic factors in early-stage cervical squamous carcinoma; to explore the expression of P53, COX2 and CD44V6 in early stage squamous carcinoma of cervix and its relationship with prognosis.

METHODS

A case-controlled study was conducted to compare LVSI positive group (n = 44) in early stage squamous carcinoma of cervix with LVSI negative group (n = 44). Expression of P53, COX2 and CD44V6 were evaluated by immunohistochemical method to analyze the relationship between LVSI, P53, COX2 and CD44V6 and various clinicopathologic factors and to investigate their prognostic influences.

RESULTS

LVSI positive was correlated with lymph node metastasis and deep stromal invasion. The 5-year disease-free survival was 68.9% in LVSI positive group versus 94.7% in LVSI negative group (P < 0.01). And the 5-year overall survival was 70.2% in LVSI positive group versus 100% in LVSI negative group (P < 0.01) with a significant difference. COX2 was correlated with clinical stage and tumor volume while there was no correlation with P53, CD44V6 and clinical factors. The overall survival of P53, COX2 and CD44V6 positive cases were significantly shorter than that of negative ones, especially in constant positive cases of 3 markers (disease-free survival 60.0 months shorter than constant negative cases with an overall survival of 91.3 months, but there was no significant difference).

CONCLUSION

LVSI is correlated with lymph node metastasis and deep stromal invasion in the early-stage squamous carcinoma of cervix while it is negatively correlated with disease-free survival and overall survival. COX2 is correlated with clinical stage and tumor volume. Furthermore P53 and CD44V6 are not correlated with clinical factors. The overall survival of P53, COX2 and CD44V6 positive cases are significantly shorter than that of negative ones.

摘要

目的

探讨早期宫颈鳞状细胞癌中淋巴管间隙浸润（LVSI）与各种临床病理因素之间的关系；探究P53、COX2和CD44V6在早期宫颈鳞状细胞癌中的表达及其与预后的关系。

方法

进行病例对照研究，比较早期宫颈鳞状细胞癌中LVSI阳性组（n = 44）和LVSI阴性组（n = 44）。采用免疫组织化学方法评估P53、COX2和CD44V6的表达，分析LVSI、P53、COX2和CD44V6与各种临床病理因素之间的关系，并研究它们对预后的影响。

结果

LVSI阳性与淋巴结转移和深层间质浸润相关。LVSI阳性组的5年无病生存率为68.9%，而LVSI阴性组为94.7%（P < 0.01）。LVSI阳性组的5年总生存率为70.2%，而LVSI阴性组为100%（P < 0.01），差异有统计学意义。COX2与临床分期和肿瘤体积相关，而与P53、CD44V6及临床因素无关。P53、COX2和CD44V6阳性病例的总生存期明显短于阴性病例，尤其是在三种标志物均持续阳性的病例中（无病生存期比持续阴性病例短60.0个月，总生存期为91.3个月，但差异无统计学意义）。