Programa en Ganadería, Campus Montecillo, Colegio de Postgraduados, Texcoco, Estado de México, México.
Theriogenology. 2010 Jul 1;74(1):100-4. doi: 10.1016/j.theriogenology.2010.01.019. Epub 2010 Mar 7.
The objectives were to test the hypothesis that exogenous prostaglandin F(2alpha) (PGF(2alpha)) temporarily restores sexual behavior of castrated boars, and to evaluate effects of PGF(2alpha) on serum hormone concentrations. At 35 d after castration, nine lean-type adult boars were randomly assigned to three treatments in a 3x3 latin square (with three replicates). Treatments were three doses of PGF(2alpha) doses (0, 10, and 20mg) and three periods of treatment, with 5 d between each period. Serum testosterone (T) concentrations were non-detectable at the start of the experiment. Serum concentrations of estradiol (E2), LH, prolactin (PRL), and cortisol were unaffected (P>0.05) by PGF(2alpha) treatment. The interval from treatment to ejaculation in boars treated with 10mg (758s) or 20mg (660s) PGF(2alpha) did not differ, but were different (P < 0.05) from control boars (>1 800s). Ejaculation duration and false mounts differed (P < 0.05) between control boars and boars treated with 10 or 20mg PGF(2alpha). In conclusion, PGF(2alpha) treatment did not change serum concentrations of T, E2, LH, PRL, or cortisol, but restored sexual behavior. This restoration may have been due to an effect of PGF(2alpha) directly in specific areas of the brain, or indirectly via release of other hormones that stimulated areas in the brain that affected sexual behavior.
目的是检验外源性前列腺素 F(2alpha)(PGF(2alpha))是否能暂时恢复去势公猪的性行为的假说，并评估 PGF(2alpha)对血清激素浓度的影响。在去势后 35 天，9 头瘦型成年公猪被随机分配到 3x3 拉丁方（3 个重复）的 3 个处理中。处理为 3 种 PGF(2alpha)剂量（0、10 和 20mg）和 3 个治疗期，每个治疗期之间间隔 5 天。实验开始时，血清睾酮（T）浓度无法检测到。PGF(2alpha)处理对血清雌二醇（E2）、LH、催乳素（PRL）和皮质醇浓度没有影响（P>0.05）。用 10mg（758s）或 20mg（660s）PGF(2alpha)处理的公猪从治疗到射精的间隔时间没有差异，但与对照公猪（>1800s）不同（P < 0.05）。对照组公猪和用 10 或 20mg PGF(2alpha)处理的公猪的射精持续时间和假交配不同（P < 0.05）。总之，PGF(2alpha)处理没有改变 T、E2、LH、PRL 或皮质醇的血清浓度，但恢复了性行为。这种恢复可能是由于 PGF(2alpha)直接作用于大脑的特定区域，或间接通过释放其他刺激大脑中影响性行为的区域的激素而引起的。
