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Unusual DNA binding modes for metal anticancer complexes.金属抗癌配合物的异常DNA结合模式。
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The influence of Cisplatin on the gas-phase dissociation of oligonucleotides studied by electrospray ionization tandem mass spectrometry.顺铂对通过电喷雾电离串联质谱法研究的寡核苷酸气相解离的影响。
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Modulation of the metastatic progression of breast cancer with an organometallic ruthenium compound.一种有机金属钌化合物对乳腺癌转移进程的调控
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High resolution mass spectrometry for studying the interactions of cisplatin with oligonucleotides.用于研究顺铂与寡核苷酸相互作用的高分辨率质谱法。
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Synthesis, Characterization and Solution Chemistry of trans-Indazoliumtetrachlorobis(Indazole)Ruthenate(III), a New Anticancer Ruthenium Complex. IR, UV, NMR, HPLC Investigations and Antitumor Activity. Crystal Structures of trans-1-Methyl-Indazoliumtetrachlorobis-(1-Methylindazole)Ruthenate(III) and its Hydrolysis Product trans-Monoaquatrichlorobis-(1-Methylindazole)-Ruthenate(III).新型抗癌钌配合物反式四氯双（吲唑）钌酸（III）合吲唑鎓的合成、表征及溶液化学。红外光谱、紫外光谱、核磁共振、高效液相色谱研究及抗肿瘤活性。反式-1-甲基-吲唑鎓四氯双（1-甲基吲唑）钌酸（III）及其水解产物反式一水三氯双（1-甲基吲唑）钌酸（III）的晶体结构
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钌与铂：电喷雾电离质谱法研究抗癌金属药物与双链寡核苷酸的相互作用。

Ruthenium versus platinum: interactions of anticancer metallodrugs with duplex oligonucleotides characterised by electrospray ionisation mass spectrometry.

机构信息

Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, Switzerland.

出版信息

J Biol Inorg Chem. 2010 Jun;15(5):677-88. doi: 10.1007/s00775-010-0635-0. Epub 2010 Mar 7.

DOI:10.1007/s00775-010-0635-0
PMID:20213306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6485486/
Abstract

The binding of the ruthenium-based anticancer drug candidates KP1019, NAMI-A and RAPTA-T towards different double-stranded oligonucleotides was probed by electrospray ionisation mass spectrometry and compared with that of the widely used platinum-based chemotherapeutics cisplatin, carboplatin and oxaliplatin. It was found that the extent of adduct formation decreased in the following order: cisplatin > oxaliplatin > NAMI-A > RAPTA-T > carboplatin > KP1019. In addition to the characterisation of the adducts formed with the DNA models, the binding sites of the metallodrugs on the oligonucleotides were elucidated employing top-down tandem mass spectrometry and were found to be similar for all the metallodrugs studied, irrespective of the sequence of the oligonucleotide. A strong preference for guanine residues was established.

摘要

通过电喷雾电离质谱法研究了钌基抗癌候选药物 KP1019、NAMI-A 和 RAPTA-T 与不同双链寡核苷酸的结合，并将其与广泛使用的铂类化疗药物顺铂、卡铂和奥沙利铂进行了比较。结果发现，加合物的形成程度按以下顺序降低：顺铂>奥沙利铂>NAMI-A>RAPTA-T>卡铂>KP1019。除了对 DNA 模型形成的加合物进行表征外，还使用自上而下的串联质谱法阐明了金属药物在寡核苷酸上的结合位点，结果表明，所有研究的金属药物的结合位点都相似，与寡核苷酸的序列无关。确定了对鸟嘌呤残基的强烈偏好。