Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, United Kingdom.
Mov Disord. 2010 Apr 15;25(5):638-42. doi: 10.1002/mds.22902.
There is growing awareness of impulsive-compulsive spectrum behaviors (ICBs) in patients with Parkinson's disease (PD) treated with dopamine replacement therapy (DRT). These include pathological gambling, hypersexuality, compulsive shopping, binge eating, punding and compulsive use of DRT, or dopamine dysregulation syndrome. In PD, difficulties exist in separating the effects of DRT from the underlying disease process and aberrant dopaminergic systems in determining the aetiology of ICBs. Recent reports of ICBs associated with dopamine agonist use for conditions other than PD may suggest a significant etiological role for these medications, but currently published cases thus far lack pathological confirmation of diagnoses. We present three cases of pathologically confirmed progressive supranuclear palsy who developed ICBs in association with dopamine agonist use. Pathological comparisons between these three cases and other case series of progressive supranuclear palsy are made.
人们越来越意识到接受多巴胺替代疗法（DRT）治疗的帕金森病（PD）患者存在冲动-强迫谱系行为（ICBs）。这些行为包括病理性赌博、性欲亢进、强迫性购物、暴食、刻板行为和强迫性使用 DRT 或多巴胺失调综合征。在 PD 中，从根本疾病过程和异常多巴胺能系统中分离 DRT 的影响以确定 ICBs 的病因存在困难。最近有报道称，除 PD 以外的其他疾病使用多巴胺激动剂也会引起 ICBs，这可能表明这些药物具有重要的病因作用，但目前已发表的病例缺乏对诊断的病理确认。我们报告了三例经病理证实的进行性核上性麻痹患者，他们在使用多巴胺激动剂时出现了 ICBs。对这三个病例和其他进行性核上性麻痹病例系列的病理比较进行了说明。
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