新生儿肺动脉高压。
Neonatal pulmonary hypertension.
机构信息
Division of Neonatology, Children's Memorial Hospital, Northwestern University's Feinberg School of Medicine, Chicago, IL, USA.
出版信息
Pediatr Crit Care Med. 2010 Mar;11(2 Suppl):S79-84. doi: 10.1097/PCC.0b013e3181c76cdc.
Abstract
When the normal cardiopulmonary transition fails to occur, the result is persistent pulmonary hypertension of the newborn. Severe persistent pulmonary hypertension of the newborn is estimated to occur in 2 per 1000 live-born term infants, and some degree of pulmonary hypertension complicates the course of >10% of all neonates with respiratory failure. This review article discusses the vascular abnormalities that are associated with neonatal pulmonary hypertension, including recognition of its role in severe bronchopulmonary dysplasia in preterm infants. A systematic review of the evidence for common therapies including inhaled nitric oxide, high-frequency ventilation, surfactant, and extracorporeal life support is included. Finally, this field is rapidly evolving, and the rationale for promising new treatment approaches is reviewed, including inhibition of phosphodiesterases and scavengers of reactive oxygen species.
摘要
当正常的心肺过渡未能发生时，结果就是新生儿持续性肺动脉高压。据估计，严重的新生儿持续性肺动脉高压每 1000 例足月产活婴中就有 2 例，而>10%患有呼吸衰竭的所有新生儿的病程中都有某种程度的肺动脉高压。本文讨论了与新生儿肺动脉高压相关的血管异常，包括其在早产儿严重支气管肺发育不良中的作用。对包括吸入一氧化氮、高频通气、表面活性剂和体外生命支持在内的常见疗法的证据进行了系统评价。最后，该领域正在迅速发展，本文还回顾了有前途的新治疗方法的基本原理，包括磷酸二酯酶抑制剂和活性氧清除剂。
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本文引用的文献
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J Pediatr. 2009 Dec;155(6):841-847.e1. doi: 10.1016/j.jpeds.2009.06.012.
2
Bringing down the ROS: a new therapeutic approach for PPHN.
Am J Physiol Lung Cell Mol Physiol. 2008 Dec;295(6):L976-8. doi: 10.1152/ajplung.90515.2008. Epub 2008 Oct 17.
3
Superoxide dismutase restores eNOS expression and function in resistance pulmonary arteries from neonatal lambs with persistent pulmonary hypertension.
Am J Physiol Lung Cell Mol Physiol. 2008 Dec;295(6):L979-87. doi: 10.1152/ajplung.90238.2008. Epub 2008 Sep 12.
4
Reactive oxygen species from NADPH oxidase contribute to altered pulmonary vascular responses in piglets with chronic hypoxia-induced pulmonary hypertension.
Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L881-8. doi: 10.1152/ajplung.00047.2008. Epub 2008 Aug 29.
5
Hyperoxia increases phosphodiesterase 5 expression and activity in ovine fetal pulmonary artery smooth muscle cells.
Circ Res. 2008 Feb 1;102(2):226-33. doi: 10.1161/CIRCRESAHA.107.161463. Epub 2007 Nov 8.
6
Prenatal exposure to fluoxetine induces fetal pulmonary hypertension in the rat.
Am J Respir Crit Care Med. 2007 Nov 15;176(10):1035-40. doi: 10.1164/rccm.200701-163OC. Epub 2007 Aug 16.
7
Pulmonary hemodynamics in neonatal lambs resuscitated with 21%, 50%, and 100% oxygen.
Pediatr Res. 2007 Sep;62(3):313-8. doi: 10.1203/PDR.0b013e3180db29fe.
8
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9
Early inhaled nitric oxide therapy for term and near-term newborn infants with hypoxic respiratory failure: neurodevelopmental follow-up.
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10
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