在阿尔茨海默病型痴呆中，软膜下β/A4淀粉样蛋白沉积发生在星形胶质细胞突起之间。

Subpial beta/A4 amyloid deposition occurs between astroglial processes in Alzheimer-type dementia.

作者信息

Yamaguchi H, Nakazato Y, Yamazaki T, Shoji M, Kawarabayashi T, Hirai S

机构信息

College of Medical Care and Technology, Gunma University, Japan.

出版信息

Neurosci Lett. 1991 Feb 25;123(2):217-20. doi: 10.1016/0304-3940(91)90934-l.

DOI:10.1016/0304-3940(91)90934-l

PMID:2027535

Abstract

We examined the ultrastructure of subpial beta/A4 amyloid deposits in the brains of patients with Alzheimer-type dementia. A few amyloid fibrils were found between thick astroglial processes (glia limitans). We also examined the ultrastructural localization of beta/A4 protein by the indirect immunoperoxidase technique. Electron-dense immunoreactive products scattered sporadically in the subpial areas were observed between astroglial processes. The labeling was fibrillar and/or amorphous. Subpial beta/A4 deposition may occur between astroglial processes as amorphous pre-amyloid and amyloid fibrils.

摘要

我们研究了阿尔茨海默型痴呆患者大脑软膜下β/A4淀粉样蛋白沉积物的超微结构。在粗大的星形胶质细胞突起（胶质界膜）之间发现了一些淀粉样纤维。我们还通过间接免疫过氧化物酶技术研究了β/A4蛋白的超微结构定位。在星形胶质细胞突起之间观察到电子致密的免疫反应产物散在分布于软膜下区域。标记物呈纤维状和/或无定形。软膜下β/A4沉积可能以无定形前淀粉样蛋白和淀粉样纤维的形式出现在星形胶质细胞突起之间。