长期使用非甾体抗炎药会增加成人期哮喘的发病风险：一项基于人群的随访研究。

Regular use of non-steroidal anti-inflammatory drugs increases the risk of adult-onset asthma: a population-based follow-up study.

作者信息

Thomsen Simon Francis, Kyvik Kirsten Ohm, Skadhauge Lars Rauff, Steffensen Ida, Backer Vibeke

机构信息

Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark.

出版信息

Clin Respir J. 2009 Apr;3(2):82-4. doi: 10.1111/j.1752-699X.2008.00113.x.

DOI:10.1111/j.1752-699X.2008.00113.x

PMID:20298382

Abstract

BACKGROUND

Little is known about the relation between regular use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of asthma at the population level. The aim of this study was to examine a possible association between intake of NSAIDs and risk of adult-onset asthma.

METHODS

Using data from two multidisciplinary postal questionnaire surveys concerning health and lifestyle, we prospectively studied 19 349 adult twins enrolled in the nationwide Danish Twin Registry.

RESULTS

We found a higher prevalence of new-onset asthma in subjects who used NSAIDs (other than aspirin) regularly compared with non-users (7.7% vs 4.3%), OR = 1.87 (1.25-2.81), P = 0.002. The result remained significant after adjusting for sex, age, smoking, BMI, hay fever, eczema and intake of medications other than NSAIDs, OR = 1.90 (1.26-2.85), P = 0.002.

CONCLUSIONS

Regular use of NSAIDs other than aspirin may be a risk factor for adult-onset asthma. This observation must be accommodated in explanations of the relationship between use of analgesics and risk of asthma.

摘要

背景

在人群层面，关于非甾体抗炎药（NSAIDs）的常规使用与哮喘风险之间的关系，人们了解甚少。本研究的目的是探讨NSAIDs的摄入与成人期哮喘风险之间可能存在的关联。

方法

利用两项关于健康和生活方式的多学科邮政问卷调查数据，我们对丹麦全国双胞胎登记处登记的19349对成年双胞胎进行了前瞻性研究。

结果

我们发现，与未使用者相比，经常使用NSAIDs（不包括阿司匹林）的受试者中，新发哮喘的患病率更高（7.7%对4.3%），比值比（OR）=1.87（1.25 - 2.81），P = 0.002。在对性别、年龄、吸烟、体重指数（BMI）、花粉症、湿疹以及NSAIDs以外的药物摄入进行调整后，结果仍然显著，OR = 1.90（1.26 - 2.85），P = 0.002。