成年亚洲印度人的载脂蛋白E基因多态性与血脂异常：来自印度加尔各答的一项基于人群的研究。
Apolipoprotein E gene polymorphism and dyslipidaemia in adult Asian Indians: A population based study from Calcutta, India.
作者信息
Das Mithun, Pal Susil, Ghosh Arnab
机构信息
Post Graduate Department of Anthropology, Sree Chaitanya College, Habra, West Bengal, India.
出版信息
Indian J Hum Genet. 2008 Sep;14(3):87-91. doi: 10.4103/0971-6866.45000.
AIM
The study was aimed to determine the association of Apolipoprotein E (apo E) gene polymorphisms on lipid levels in Asian Indian population.
METHODS
A total of 350 (184 males and 166 females) adult (30 years and above) Asian Indians of Calcutta and suburb participated in the study. Anthropometric measures, lipids profiles, and blood glucose measures were collected. Out of 350 subjects, a sample of 70 individuals was selected randomly for genotyping after adjusting for age and sex. The apo E gene polymorphisms were determined by agarose gel electrophoresis.
RESULTS
The apo E polymorphism showed significant association with dyslipidaemia (P=0.0135) with epsilon3/4 combination has had the highest occurrence of dyslipidaemia and metabolic syndrome (MS) followed by epsilon4/4 <epsilon3/3 <epsilon2/4 <epsilon2/3 in decreasing order.
CONCLUSIONS
The epsilon4 allele of apo E gene independent of other risk factors is associated with dyslipidaemia in particular with low HDLc and high TC: HDLc ratio.
目的
本研究旨在确定亚洲印度人群中载脂蛋白E（apo E）基因多态性与血脂水平的关联。
方法
共有350名（184名男性和166名女性）来自加尔各答及其郊区的成年（30岁及以上）亚洲印度人参与了本研究。收集了人体测量指标、血脂谱和血糖指标。在350名受试者中，在对年龄和性别进行调整后，随机选择70名个体进行基因分型。通过琼脂糖凝胶电泳确定apo E基因多态性。
结果
apo E基因多态性与血脂异常显著相关（P = 0.0135），其中ε3/4组合的血脂异常和代谢综合征（MS）发生率最高，其次是ε4/4 < ε3/3 < ε2/4 < ε2/3，呈递减顺序。
结论
apo E基因的ε4等位基因独立于其他危险因素，与血脂异常相关，特别是与低HDLc和高TC:HDLc比值相关。
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