特发性儿童局灶性癫痫的脑电图广泛特征。

Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Songpa-ku, Seoul 138-736, Republic of Korea.

Seizure. 2010 May;19(4):222-5. doi: 10.1016/j.seizure.2010.02.006. Epub 2010 Mar 19.

PURPOSE

Idiopathic focal epilepsies in childhood including benign childhood epilepsy with occipital paroxysms (BEOP) or benign childhood epilepsy with centro-temporal spikes (BCECTS) are characterized by specific focal electrographic patterns as the name indicates. Generalized spike-wave discharges in children with idiopathic focal epilepsy can suggest a neurobiological continuum with the idiopathic generalized epilepsies. We assessed the prevalence of generalized epileptiform discharges and generalized seizures in BEOP/BCECTS patients.

METHODS

Between August 2005 and November 2008, we identified 220 cases with electroclinical features typical of idiopathic focal epilepsies, 172 patients with BCECTS and 48 patients with BEOP, excluding patients whose neurological examinations or brain MRI were abnormal. We analyzed gender, age at onset, manifestation of generalized seizures, and serial EEG records to detect generalized abnormalities.

RESULTS

Of our population, 42 patients (19.1%, 22 boys), 30 (17.4%) of 172 BCECTS patients and 12 (25.0%) of 48 BEOP patients, showed generalized spike-wave discharges once or more during follow-up. The typical 3-Hz generalized spike wave discharge was noticed in 7 patients and concurrence with clinical generalized seizure was observed in 11.

CONCLUSION

A relatively high incidence of generalized spike-wave discharge and concurrence with generalized seizure were observed in patients with BEOP/BCECTS, with the incidence being higher in BEOP patients than in those with BCECTS. It may be inferred that idiopathic focal epilepsy is not a fixed syndrome but is a part of a broad, age-related, benign, seizure susceptibility syndrome.

目的

特发性局灶性癫痫包括良性儿童枕叶癫痫伴发作（BEOP）或良性儿童颞叶癫痫伴中央颞区棘波（BCECTS），其特征在于特定的局灶性脑电图模式，正如其名称所示。特发性局灶性癫痫儿童的全身性棘慢波放电可能提示与特发性全面性癫痫存在神经生物学连续性。我们评估了 BEOP/BCECTS 患者中全身性癫痫样放电和全身性发作的发生率。

方法

在 2005 年 8 月至 2008 年 11 月期间，我们确定了 220 例具有特发性局灶性癫痫临床特征的患者，其中 172 例为 BCECTS 患者，48 例为 BEOP 患者，排除了神经系统检查或脑 MRI 异常的患者。我们分析了性别、发病年龄、全身性发作的表现以及连续脑电图记录以检测全身性异常。

结果

在我们的患者群体中，42 例（19.1%，22 例为男性），即 30 例（17.4%）172 例 BCECTS 患者和 12 例（25.0%）48 例 BEOP 患者，在随访过程中出现了一次或多次全身性棘波-慢波放电。在 7 例患者中注意到典型的 3Hz 全身性棘波放电，11 例患者中观察到与临床全身性发作同时出现。