原发性干燥综合征患者循环系统中含免疫球蛋白A的免疫复合物

IgA-containing immune complexes in the circulation of patients with primary Sjögren's syndrome.

作者信息

Bendaoud B, Pennec Y L, Lelong A, Le Noac'h J F, Magadur G, Jouquan J, Youinou P

机构信息

Laboratory of Immunology, Brest University Medical School Hospital, France.

出版信息

J Autoimmun. 1991 Feb;4(1):177-84. doi: 10.1016/0896-8411(91)90016-6.

DOI:10.1016/0896-8411(91)90016-6

PMID:2031660

Abstract

IgA-, IgM- and IgG-containing immune complexes (CIC) were detected in 48, 19 and 12% of 52 patients with primary Sjögren's syndrome (SS), in 36, 38 and 56% of 45 patients with rheumatoid arthritis, and in 8, 5 and 3% of 40 normal controls. A high proportion of primary SS patients also had considerable amounts of serum IgA and elevated levels of IgA with rheumatoid factor (RF) activity. IgA-CIC and IgA-RF were more frequent (P less than 0.03 and less than 0.001) in the 27 primary SS patients with, than in the 25 without extraglandular manifestations. IgA-CIC could play a role in mediating the tissue injury associated with primary SS.

摘要

在52例原发性干燥综合征（SS）患者中，48%、19%和12%的患者检测到含IgA、IgM和IgG的免疫复合物（CIC）；在45例类风湿关节炎患者中，这一比例分别为36%、38%和56%；而在40名正常对照者中，相应比例为8%、5%和3%。相当一部分原发性SS患者还存在大量血清IgA以及类风湿因子（RF）活性升高的IgA水平。在27例有腺外表现的原发性SS患者中，IgA - CIC和IgA - RF比25例无腺外表现的患者更常见（P分别小于0.03和0.001）。IgA - CIC可能在介导与原发性SS相关的组织损伤中发挥作用。