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饮食在炎症性肠病管理中的作用。

Role of diet in the management of inflammatory bowel disease.

机构信息

Department of General Surgery, 3rd Floor, St James Wing, St George's Hospital, Blackshaw Road, Tooting, London, SW17 0QT, UK.

出版信息

World J Gastroenterol. 2010 Mar 28;16(12):1442-8. doi: 10.3748/wjg.v16.i12.1442.

Abstract

Many studies have looked at connections between diet, etiology, signs and symptoms associated with inflammatory bowel disease (IBD). Although these connections are apparent to clinicians, they are difficult to prove qualitatively or quantitatively. Enteral feeding and polymeric diets are equally effective at bringing about remission in Crohn's disease (CD). Parenteral feeding is also effective, although none of these methods is as effective as corticosteroid therapy. However, enteral feeding is preferred in the pediatric population because linear growth is more adequately maintained via this route. Exclusion diets in patients brought into remission using an elemental diet have been shown to maintain remission for longer periods. Studies that aim to isolate culpable food groups have shown that individuals react differently on exposure to or exclusion of various foods. The commonly identified food sensitivities are cereals, milk, eggs, vegetables and citrus fruits. Studies that have looked at gut mucosal antigen behavior have shown higher rectal blood flow, in response to specific food antigens, in those with CD over healthy subjects. Exclusion of sugar shows little evidence of amelioration in CD. Omega 3 fatty acids show promise in the treatment of IBD but await larger randomized controlled trials. Patients frequently notice that specific foods cause aggravation of their symptoms. Whilst it has been difficult to pinpoint specific foods, with advances in the laboratory tests and food supplements available, the aim is to prolong remission in these patients using dietary measures, and reduce the need for pharmacotherapy and surgical intervention.

摘要

许多研究都着眼于饮食、病因、与炎症性肠病(IBD)相关的体征和症状之间的联系。虽然这些联系对临床医生来说是显而易见的,但很难从定性或定量的角度证明它们的存在。肠内喂养和聚合饮食在克罗恩病(CD)的缓解中同样有效。肠外营养也是有效的,尽管这些方法都不如皮质类固醇治疗有效。然而,在儿科人群中,肠内喂养更受欢迎,因为通过这种途径更能充分维持线性生长。通过使用要素饮食使患者缓解后进行排除饮食,已被证明能维持更长时间的缓解期。旨在分离致病食物组的研究表明,个体在接触或排除各种食物时的反应不同。常见的食物过敏是谷物、牛奶、鸡蛋、蔬菜和柑橘类水果。研究肠道黏膜抗原行为的研究表明,CD 患者对特定食物抗原的直肠血流反应高于健康受试者。排除糖对 CD 的改善作用证据不足。ω-3 脂肪酸在治疗 IBD 方面有一定的前景,但需要更大规模的随机对照试验。患者经常注意到某些食物会加重他们的症状。虽然很难确定具体的食物,但随着实验室测试和食品补充剂的进步,其目的是通过饮食措施延长这些患者的缓解期,并减少对药物治疗和手术干预的需求。

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引用本文的文献

本文引用的文献

1
Enteral nutrition for maintenance of remission in Crohn's disease.肠内营养用于维持克罗恩病的缓解状态。
Cochrane Database Syst Rev. 2007 Jul 18(3):CD005984. doi: 10.1002/14651858.CD005984.pub2.
2
Enteral nutritional therapy for induction of remission in Crohn's disease.肠内营养疗法诱导克罗恩病缓解
Cochrane Database Syst Rev. 2007 Jan 24(1):CD000542. doi: 10.1002/14651858.CD000542.pub2.
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Effects of dietary fiber on inflammatory bowel disease.膳食纤维对炎症性肠病的影响。
Mol Nutr Food Res. 2005 Jun;49(6):601-8. doi: 10.1002/mnfr.200500013.

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