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Murine cerebral malaria: how far from human cerebral malaria?小鼠脑型疟疾：与人类脑型疟疾相差多远？
Trends Parasitol. 2010 Jun;26(6):271-2. doi: 10.1016/j.pt.2010.03.001. Epub 2010 Mar 23.
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Cerebral malaria: human versus mouse studies.脑型疟疾：人类与小鼠研究
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Murine cerebral malaria: the whole story.小鼠脑型疟疾：完整的故事。
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Cerebral malaria: in praise of epistemes.脑型疟疾：对知识体系的赞颂。
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In vitro culture of Plasmodium berghei-ANKA maintains infectivity of mouse erythrocytes inducing cerebral malaria.体外培养伯氏疟原虫-ANKA 保持感染性，可诱导小鼠红细胞发生脑型疟疾。
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The role of animal models for research on severe malaria.动物模型在重症疟疾研究中的作用。
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Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine.鼠脑型疟疾与类似血管痉挛的微循环功能障碍有关，而用尼莫地平进行抢救治疗后，存活率明显提高。
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Methods Mol Biol. 2025;2876:93-103. doi: 10.1007/978-1-0716-4252-8_6.
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Investigation of Plasma-Derived Lipidome Profiles in Experimental Cerebral Malaria in a Mouse Model Study.实验性脑疟疾小鼠模型中血浆衍生脂质组谱的研究。
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Whole blood transfusion improves vascular integrity and increases survival in artemether-treated experimental cerebral malaria.全血输血可改善血管完整性并提高青蒿琥酯治疗的实验性脑疟疾的存活率。
Sci Rep. 2021 Jun 8;11(1):12077. doi: 10.1038/s41598-021-91499-3.
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Perillyl alcohol reduces parasite sequestration and cerebrovascular dysfunction during experimental cerebral malaria.紫苏醇可减轻实验性脑型疟期间的寄生虫滞留和脑血管功能障碍。
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Using two phases of the CD4 T cell response to blood-stage murine malaria to understand regulation of systemic immunity and placental pathology in Plasmodium falciparum infection.利用 CD4 T 细胞对血期疟原虫的两个反应阶段来理解恶性疟原虫感染中系统性免疫和胎盘病理的调节。
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Endothelin-1 Treatment Induces an Experimental Cerebral Malaria-Like Syndrome in C57BL/6 Mice Infected with Plasmodium berghei NK65.内皮素-1治疗可在感染伯氏疟原虫NK65的C57BL/6小鼠中诱发类似实验性脑型疟疾的综合征。
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Dysregulation of the haem-haemopexin axis is associated with severe malaria in a case-control study of Ugandan children.在乌干达儿童的一项病例对照研究中，血红素-血红素结合蛋白轴失调与严重疟疾有关。
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本文引用的文献

1
Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine.鼠脑型疟疾与类似血管痉挛的微循环功能障碍有关，而用尼莫地平进行抢救治疗后，存活率明显提高。
Am J Pathol. 2010 Mar;176(3):1306-15. doi: 10.2353/ajpath.2010.090691. Epub 2010 Jan 28.
2
Cerebral malaria: a vasculopathy.脑型疟疾：一种血管病变。
Am J Pathol. 2010 Mar;176(3):1075-8. doi: 10.2353/ajpath.2010.091090. Epub 2010 Jan 21.
3
Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease.脑型疟疾：为何需要实验性鼠疟疾模型来了解疾病的发病机制。
Parasitology. 2010 Apr;137(5):755-72. doi: 10.1017/S0031182009991715. Epub 2009 Dec 23.
4
Platelet-endothelial cell interactions in cerebral malaria: the end of a cordial understanding.血小板-内皮细胞相互作用在脑型疟疾中的作用：一种亲切理解的终结。
Thromb Haemost. 2009 Dec;102(6):1093-102. doi: 10.1160/TH09-05-0337.
5
The murine cerebral malaria phenomenon.鼠脑型疟疾现象。
Trends Parasitol. 2010 Jan;26(1):11-5. doi: 10.1016/j.pt.2009.10.007. Epub 2009 Nov 22.
6
IP-10-mediated T cell homing promotes cerebral inflammation over splenic immunity to malaria infection.IP-10介导的T细胞归巢促进脑部炎症，而非脾脏对疟疾感染的免疫反应。
PLoS Pathog. 2009 Apr;5(4):e1000369. doi: 10.1371/journal.ppat.1000369. Epub 2009 Apr 3.
7
Characterization of cerebral malaria in the outbred Swiss Webster mouse infected by Plasmodium berghei ANKA.对受伯氏疟原虫ANKA感染的远交系瑞士韦伯斯特小鼠脑型疟疾的特征描述。
Int J Exp Pathol. 2009 Apr;90(2):119-30. doi: 10.1111/j.1365-2613.2008.00622.x.
8
Perfusion abnormalities in children with cerebral malaria and malarial retinopathy.脑型疟疾和疟疾性视网膜病变患儿的灌注异常。
J Infect Dis. 2009 Jan 15;199(2):263-71. doi: 10.1086/595735.
9
Arginine, nitric oxide, carbon monoxide, and endothelial function in severe malaria.精氨酸、一氧化氮、一氧化碳与重症疟疾中的内皮功能
Curr Opin Infect Dis. 2008 Oct;21(5):468-75. doi: 10.1097/QCO.0b013e32830ef5cf.
10
Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration.鼠疟原虫滞留：CD36是主要受体，但脑部病理与滞留无关。
Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11468-73. doi: 10.1073/pnas.0503386102. Epub 2005 Jul 28.

Murine cerebral malaria: how far from human cerebral malaria?

作者信息

Carvalho Leonardo J M

出版信息

Trends Parasitol. 2010 Jun;26(6):271-2. doi: 10.1016/j.pt.2010.03.001. Epub 2010 Mar 23.

DOI:10.1016/j.pt.2010.03.001
PMID:20335068
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2883649/
Abstract
摘要