蝙蝠葛堿作为心血管保护剂的药理作用。
Pharmacological effects of rutaecarpine as a cardiovascular protective agent.
机构信息
Department of Pharmaceutics, The Third XiangYa Hospital of Central South University, Changsha 410013, China.
出版信息
Molecules. 2010 Mar 15;15(3):1873-81. doi: 10.3390/molecules15031873.
Abstract
Many studies indicate that traditional Chinese herbs are beneficial in the prevention and treatment of cardiovascular diseases. Evodia rutaecarpa ('Wu-Chu-Yu') remains the most popular and multi-purpose herb traditionally used in China for treatment of headache, abdominal pain, postpartum hemorrhage, dysentery and amenorrhea. Rutaecarpine is one of the intriguing indolopyridoquinazoline alkaloids isolated from 'Wu-Chu-Yu'. Rutaecarpine has been shown to have cardiovascular biological effects such as inotropic and chronotropic, vasorelaxant, anti-platelet aggregation and anti-inflammatory effects. Furthermore, it has been reported that rutaecarpine has beneficial effects on some cardiovascular diseases. This review summarizes data on the cardiovascular pharmacological actions of rutaecarpine the published over the recent years, aiming to provide more evidence supporting its use in the treatment of cardiovascular diseases.
摘要
许多研究表明，中草药在心血管疾病的预防和治疗中具有益处。吴茱萸（Evodia rutaecarpa）仍然是中国传统上最受欢迎和用途最广泛的草药，用于治疗头痛、腹痛、产后出血、痢疾和闭经。吴茱萸堿（Rutaecarpine）是从吴茱萸中分离出来的具有吸引力的吲哚并吡啶喹嗪生物碱之一。吴茱萸堿具有正性肌力和正性频率、血管舒张、抗血小板聚集和抗炎等心血管生物学作用。此外，据报道，吴茱萸堿对一些心血管疾病具有有益的作用。本综述总结了近年来发表的关于吴茱萸堿心血管药理作用的资料，旨在为其在心血管疾病治疗中的应用提供更多证据支持。
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