Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.
Trends Biochem Sci. 2010 Jun;35(6):323-32. doi: 10.1016/j.tibs.2010.02.009. Epub 2010 Mar 24.
The polycomb group (PcG) proteins are essential for the normal development of multicellular organisms. They form multi-protein complexes that work as transcriptional repressors of several thousand genes controlling differentiation pathways during development. How the PcG proteins work as transcriptional repressors is incompletely understood, but involves post-translational modifications of histones by two major PcG protein complexes: polycomb repressive complex 1 and polycomb repressive complex 2.
多梳蛋白复合物（PcG）蛋白对于多细胞生物的正常发育至关重要。它们形成多蛋白复合物，作为几千个基因的转录抑制剂，这些基因控制着发育过程中的分化途径。PcG 蛋白如何作为转录抑制剂发挥作用尚不完全清楚，但涉及两个主要的 PcG 蛋白复合物：多梳抑制复合物 1 和多梳抑制复合物 2 对组蛋白的翻译后修饰。
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