Han Jee Young, Lee Jin Woo, Kim Joon Mee, Joo Kowoon, Chon Ung, Lee Jung Il, Jeong Seok, Lee Don Haeng, Kim Young Soo, Min Kyung Sun
Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea.
Korean J Hepatol. 2010 Mar;16(1):75-8. doi: 10.3350/kjhep.2010.16.1.75.
Alverine citrate is one of the most commonly used antispasmodic drugs for patients with irritable bowel syndrome. Alverine-citrate-induced hepatotoxicity is extremely rare, with only a few cases having been reported worldwide. We present a case of a 75-year-old female patient who experienced complicated jaundice and abdominal discomfort after taking alverine citrate. Other causes of hepatitis were ruled out and the results of the liver function test returned to normal after ceasing the drug. This is the first case report in Korea of alverine-citrate-induced hepatotoxicity.
枸橼酸阿尔维林是肠易激综合征患者最常用的解痉药物之一。枸橼酸阿尔维林引起的肝毒性极为罕见,全球仅报道过少数病例。我们报告一例75岁女性患者,服用枸橼酸阿尔维林后出现复杂的黄疸和腹部不适。排除了其他肝炎病因,停药后肝功能检查结果恢复正常。这是韩国首例关于枸橼酸阿尔维林引起肝毒性的病例报告。