Department of Genetics, and the Broad Institute of Massachusetts Institute of Technology and Harvard, Harvard School of Public Health, Boston, Massachusetts, USA.
Nat Med. 2010 Apr;16(4):396-9. doi: 10.1038/nm0410-396.
Atherosclerosis and related cardiovascular diseases represent one of the greatest threats to human health worldwide. Despite important progress in prevention and treatment, these conditions still account for one third of all deaths annually. Often presented together with obesity, insulin resistance and type 2 diabetes, these chronic diseases are strongly influenced by pathways that lie at the interface of chronic inflammation and nutrient metabolism. Here I discuss recent advances in the study of endoplasmic reticulum stress as one mechanism that links immune response with nutrient sensing in the pathogenesis of atherosclerosis and its complications.
动脉粥样硬化和相关心血管疾病是全世界人类健康的最大威胁之一。尽管在预防和治疗方面取得了重要进展,但这些疾病仍然每年导致三分之一的死亡。这些慢性病通常与肥胖、胰岛素抵抗和 2 型糖尿病一起出现,它们受到慢性炎症和营养代谢之间界面的途径的强烈影响。在这里,我讨论了内质网应激研究的最新进展,作为将免疫反应与动脉粥样硬化发病机制中的营养感应联系起来的机制之一及其并发症。