经颅交流电刺激（tACS）可调节 TMS 诱发的闪光阂值评估的皮质兴奋性。
Transcranial alternating current stimulation (tACS) modulates cortical excitability as assessed by TMS-induced phosphene thresholds.
机构信息
Institute of Cognitive Neuroscience & Dept. of Psychology, University College London, 17 Queen Square, WC1N 3AR London, United Kingdom.
Department of Clinical Neurophysiology, Georg-August University, Robert Koch Straße 40, 37075 Göttingen, Germany.
出版信息
Clin Neurophysiol. 2010 Sep;121(9):1551-1554. doi: 10.1016/j.clinph.2010.03.022. Epub 2010 Apr 9.
OBJECTIVE
Recent developments in transcranial alternating current stimulation (tACS) provide a powerful approach to establish the functional roles of neuronal oscillatory activities in the human brain. Here, we investigated whether tACS can reach and modulate the excitability of the visual cortex in a frequency-dependent manner.
METHODS
We measured the cortical excitability of the visual cortex using single pulse transcranial magnetic stimulation (TMS) while delivering tACS to the occipital region at different frequencies (5, 10, 20 and 40 Hz).
RESULTS
We found that tACS at 20 Hz decreased TMS-phosphene threshold (i.e., increased the excitability of the visual cortex) during the stimulation, whereas other frequencies did not affect TMS-phosphene thresholds.
CONCLUSIONS
Our findings demonstrate direct interactions of tACS with the visual cortex in a frequency-dependent manner.
SIGNIFICANCE
Our present work provides further demonstration of the potential of tACS as a method to selectively modulate the excitability of the visual cortex.
目的
经颅交流电刺激（tACS）的最新发展为确定人类大脑中神经元振荡活动的功能作用提供了一种强大的方法。在这里，我们研究了 tACS 是否可以以频率依赖性的方式到达并调节视觉皮层的兴奋性。
方法
我们使用单次经颅磁刺激（TMS）测量视觉皮层的皮质兴奋性，同时在不同频率（5、10、20 和 40 Hz）下将 tACS 传递到枕叶区域。
结果
我们发现，20 Hz 的 tACS 在刺激期间降低了 TMS-闪光阈值（即增加了视觉皮层的兴奋性），而其他频率则不影响 TMS-闪光阈值。
结论
我们的发现表明 tACS 与视觉皮层之间存在直接的相互作用，这种相互作用具有频率依赖性。
意义
我们目前的工作进一步证明了 tACS 作为一种选择性调节视觉皮层兴奋性的方法的潜力。
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