瑞典乳糜泻发病率不断上升。
Increasing incidence of coeliac disease in Sweden.
作者信息
Ascher H, Krantz I, Kristiansson B
机构信息
Department of Pediatrics I, Gothenburg University, East Hospital, Sweden.
出版信息
Arch Dis Child. 1991 May;66(5):608-11. doi: 10.1136/adc.66.5.608.
Changes in the incidence of coelic disease was studied among children born in Göteborg, Sweden, between 1970 and 1988. A total of 188 patients with coeliac disease were found. Of these, 83% were less than 2 years old at the time of their first duodenal biopsy and 74% of them have so far been verified according to the criteria of the European Society for Gastroenterology and Nutrition (ESPGAN). The cumulative incidence at 2 years of age/1000 liveborn infants increased significantly from 0.31 in the first birth cohort to 2.93 in the last. This increase could only partly be explained by improvements in detection. Weight for age at diagnosis was generally considerably below the reference value, but was slightly less affected towards the end of the period. The increase in incidence of coeliac disease is the first reported since the middle 1970s and makes the disease one of the most common chronic diseases among Swedish children.
对1970年至1988年在瑞典哥德堡出生的儿童中乳糜泻发病率的变化进行了研究。共发现188例乳糜泻患者。其中，83%在首次十二指肠活检时年龄小于2岁，且根据欧洲胃肠病学和营养学会（ESPGAN）的标准，迄今已确诊74%。2岁时每1000例活产婴儿的累积发病率从第一个出生队列中的0.31显著增加到最后一个队列中的2.93。这种增加只能部分归因于检测方法的改进。诊断时的年龄别体重普遍远低于参考值，但在该时期末期受影响程度略小。乳糜泻发病率的增加是自20世纪70年代中期以来首次报告，使其成为瑞典儿童中最常见的慢性病之一。
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