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全厚皮片移植和类固醇注射在耳廓瘢痕疙瘩治疗中的作用。

The role of full-thickness skin grafting and steroid injection in the treatment of auricular keloids.

作者信息

Brown Nefertiti A, Ortega F Raymond

机构信息

Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA.

出版信息

Ann Plast Surg. 2010 May;64(5):637-8. doi: 10.1097/SAP.0b013e3181dba8aa.

Abstract

Keloids are a response to wound healing that occurs due to hyperproliferation of dermal collagen in response to skin injury (Olabanji et al, Surg Pract. 2005;9:2-7). Multiple modalities have been described in the literature to target these lesions, but treatment and prevention remain a challenge because of the high rate of recurrence (Brissett and Sherris, Facial Plast Surg. 2001;17:263-272; Kelly, Dermatol Ther. 2004;17:212-218; Robles and Berg, Clin Dermatol. 2007;25:26-32; Porter, Otolaryngol Clin North Am. 2002;35:207-220, viii). We studied the rate of recurrence of auricular keloids through a technique previously described in the literature (Converse and Stallings, Plast Reconstr Surg. 1972;49:461-463), but over a series of patients. Keloids were treated with total excision in combination with coverage of the resulting defect with a full-thickness skin graft and intradermal injection of triamcinolone acetonide solution at the periphery of the donor and recipient sites. From April 2006 to February 2007, 10 patients with auricular keloids were done using this technique, and during an 11-month follow-up no recurrence was observed. These results support that full-thickness skin grafts can be used to address keloid lesions without recurrence.

摘要

瘢痕疙瘩是皮肤损伤后真皮胶原蛋白过度增殖导致的伤口愈合反应(奥拉班吉等人,《外科实践》。2005年;9:2 - 7)。文献中描述了多种针对这些病变的治疗方法,但由于复发率高,治疗和预防仍然是一项挑战(布里塞特和谢里斯,《面部整形外科学》。2001年;17:263 - 272;凯利,《皮肤病治疗学》。2004年;17:212 - 218;罗伯斯和伯格,《临床皮肤病学》。2007年;25:26 - 32;波特,《北美耳鼻咽喉临床杂志》。2002年;35:207 - 220,viii)。我们通过文献中先前描述的一种技术(康弗斯和斯托林斯,《整形与重建外科》。1972年;49:461 - 463)研究了耳部瘢痕疙瘩的复发率,但研究对象是一系列患者。瘢痕疙瘩采用全层切除,并用全厚皮片覆盖由此产生的缺损,并在供体和受体部位周边皮内注射曲安奈德溶液进行治疗。从2006年4月至2007年2月,对10例耳部瘢痕疙瘩患者采用了这种技术,在11个月的随访期间未观察到复发。这些结果支持全厚皮片可用于治疗瘢痕疙瘩病变且不复发。

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