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血管内支架在先天性心脏病中的应用。

Use of endovascular stents in congenital heart disease.

作者信息

O'Laughlin M P, Perry S B, Lock J E, Mullins C E

机构信息

Lillie Frank Abercrombie Section of Pediatric Cardiology, Department of Pediatrics, Baylor College of Medicine, Houston, TX.

出版信息

Circulation. 1991 Jun;83(6):1923-39. doi: 10.1161/01.cir.83.6.1923.

Abstract

BACKGROUND

Balloon expandable intravascular stents have been used to support vessel walls in coronary and peripheral arteries in adults. The purpose of this study was to examine the efficacy and safety of these stents in the treatment of congenital heart disease.

METHODS AND RESULTS

Forty-five stents were placed in 30 patients, who were 0.2-30.2 years old (weight, 3.5-76 kg). Patients with areas of stenosis that were difficult to approach surgically were chosen. Stents were mounted over balloons and placed by standard catheterization techniques. Twenty-three patients had branch pulmonary artery stenosis. Thirty-six stents were placed successfully and had reduced pressure gradients from 50.6 +/- 24 to 15.9 +/- 13.4 mm Hg. Five patients had stents placed after atrial surgery: three in obstructed Fontan repairs, one at the superior vena cava-right atrial junction after sinus venous defect repair, and one at the site of a Glenn shunt. Atrial stents reduced pressure gradients from 9.8 +/- 8.2 to 2.0 +/- 2.6 mm Hg. One patient had a stent placed in the descending aorta after coarctation dilation, and the pressure gradient was reduced from 50 to 25 mm Hg. One patient had pulmonary vein dilation with stent placement. Two stents migrated at the time of placement; one required surgical removal, and one was anchored in place by balloon dilation. One patient died within 24 hours of catheterization because of thrombus obstruction of the Fontan repair. Nine patients have undergone recatheterization. All stented vessels have remained at the same caliber as at original stent placement.

CONCLUSIONS

We conclude that balloon expandable stents are useful in selected postoperative stenoses in congenital heart disease.

摘要

背景

球囊扩张式血管内支架已用于支撑成人冠状动脉和外周动脉的血管壁。本研究的目的是检验这些支架治疗先天性心脏病的有效性和安全性。

方法与结果

30例年龄在0.2至30.2岁(体重3.5至76千克)的患者植入了45个支架。选择了手术难以处理的狭窄部位的患者。支架安装在球囊上,通过标准导管技术放置。23例患者患有分支肺动脉狭窄。成功放置了36个支架,压力阶差从50.6±24降至15.9±13.4毫米汞柱。5例患者在心房手术后植入支架:3例在法洛四联症修复术后梗阻部位,1例在静脉窦缺损修复术后上腔静脉-右心房交界处,1例在格林分流部位。心房支架使压力阶差从9.8±8.2降至2.0±2.6毫米汞柱。1例患者在主动脉缩窄扩张术后在降主动脉植入支架,压力阶差从50降至25毫米汞柱。1例患者通过植入支架进行肺静脉扩张。2个支架在放置时发生移位;1个需要手术取出,1个通过球囊扩张固定在位。1例患者在导管插入术后24小时内死亡,原因是法洛四联症修复处血栓阻塞。9例患者接受了再次导管插入术。所有植入支架的血管直径均维持在最初植入支架时的水平。

结论

我们得出结论,球囊扩张式支架对先天性心脏病特定术后狭窄有用。

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