Department of Genetics, Cell Biology & Development, University of Minnesota Medical School, Minneapolis, MN, USA.
Cell Cycle. 2010 May;9(9):1759-63. doi: 10.4161/cc.9.9.11523. Epub 2010 May 15.
Cohesin proteins help maintain the physical associations between sister chromatids that arise in S-phase and are removed in anaphase. Recent studies found that cohesins also localize to the centrosomes, the organelles that organize the mitotic bipolar spindle. We find that the cohesin protein Rad21 localizes to centrosomes in a manner that is dependent upon known regulators of sister chromatid cohesion as well as regulators of centrosome function. These data suggest that Rad21 functions at the centrosome and that the regulators of Rad21 coordinate the centrosome and chromosomal functions of cohesin.
黏连蛋白有助于维持 S 期形成的姐妹染色单体之间的物理联系,并在后期被去除。最近的研究发现,黏连蛋白也定位于中心体,即组织有丝分裂双极纺锤体的细胞器。我们发现,黏连蛋白 Rad21 以依赖于已知的姐妹染色单体黏合调节剂以及中心体功能调节剂的方式定位于中心体。这些数据表明 Rad21 在中心体发挥功能,并且 Rad21 的调节剂协调黏连蛋白的中心体和染色体功能。