基于质谱的蛋白质生物标志物发现在治疗学中的应用。
The application of mass-spectrometry-based protein biomarker discovery to theragnostics.
机构信息
Centre for Cardiovascular Science, Edinburgh University, Queen's Medical Research Institute, UK.
出版信息
Br J Clin Pharmacol. 2010 Apr;69(4):367-78. doi: 10.1111/j.1365-2125.2009.03610.x.
Abstract
Over the last decade rapid developments in mass spectrometry have allowed the identification of multiple proteins in complex biological samples. This proteomic approach has been applied to biomarker discovery in the context of clinical pharmacology (the combination of biomarker and drug now being termed 'theragnostics'). In this review we provide a roadmap for early protein biomarker discovery studies, focusing on some key questions that regularly confront researchers.
摘要
在过去的十年中，质谱技术的快速发展使得在复杂的生物样本中鉴定多种蛋白质成为可能。这种蛋白质组学方法已应用于临床药理学中的生物标志物发现（现在将生物标志物和药物结合称为“治疗诊断学”）。在这篇综述中，我们为早期蛋白质生物标志物发现研究提供了路线图，重点介绍了研究人员经常面临的一些关键问题。
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