[苯二氮䓬类药物在癫痫治疗中的应用]

[Benzodiazepines in the treatment of epilepsy].

作者信息

Nakken Karl O, Rytter Elisif M, Brockmeier Frans

机构信息

Epilepsisenteret-SSE, Nevroklinikken, Oslo universitetssykehus, Rikshospitalet, Postboks 53, 1306 Baerum postterminal, Norway.

出版信息

Tidsskr Nor Laegeforen. 2010 Apr 22;130(8):842-4. doi: 10.4045/tidsskr.09.1152.

DOI:10.4045/tidsskr.09.1152

PMID:20418931

Abstract

In epilepsy benzodiazepines are mainly used to stop ongoing attacks. In hospitals intravenous diazepam is the drug of choice for status epilepticus. Outside of hospitals buccal midazolam is in the process of replacing rectal diazepam. Clonazepam, clobazam and nitrazepam (to children) are partially used as additional medication to prevent seizures.

摘要

在癫痫治疗中，苯二氮䓬类药物主要用于终止正在发作的癫痫。在医院，静脉注射地西泮是治疗癫痫持续状态的首选药物。在医院外，咪达唑仑口腔黏膜给药正在逐步取代直肠给予地西泮。氯硝西泮、氯巴占和硝西泮（用于儿童）部分用作预防癫痫发作的辅助药物。