[关于谷胱甘肽及谷胱甘肽依赖性酶抗氧化活性的当前观点]

[Current views on antioxidative activity of glutathione and glutathione-depending enzymes].

作者信息

Kalinina E V, Chernov N N, Aleud R, Novichkova M D, Saprin A N, Berezov T T

出版信息

Vestn Ross Akad Med Nauk. 2010(3):46-54.

PMID:20420216

Abstract

Reduced glutathione (GSH), gamma-glutamyl-L-cysteineglycine, is a tripeptide widespread in plants, animals, and man as a low-molecular weight SH-containing compound. This review presents results of published and original studies concerned with the synthesis and the role of glutathione and glutathione-dependent enzymes in antioxidative processes, such as maintenance and regulation of cell status, glutathionilation and deglutathionilation, redox-dependent signaling, and apoptosis.

摘要

还原型谷胱甘肽（GSH），即γ-L-谷氨酰基-L-半胱氨酰甘氨酸，是一种作为含低分子量巯基的化合物广泛存在于植物、动物及人类体内的三肽。本综述展示了已发表研究和原创研究的结果，这些研究涉及谷胱甘肽及谷胱甘肽依赖性酶在抗氧化过程中的合成与作用，如细胞状态的维持与调节、谷胱甘肽化与去谷胱甘肽化、氧化还原依赖性信号传导以及细胞凋亡。