手性毛细管电泳-胶束电动色谱法拆分顺式氯菊酯对映体：商品杀虫剂配方中的定量分析。

Enantiomeric separation of cis-bifenthrin by CD-MEKC: quantitative analysis in a commercial insecticide formulation.

机构信息

Department of Analytical Chemistry, Faculty of Chemistry, University of Alcalá, Madrid, Spain.

出版信息

Electrophoresis. 2010 May;31(9):1533-9. doi: 10.1002/elps.200900718.

DOI:10.1002/elps.200900718

PMID:20422632

Abstract

The first CE method enabling the enantiomeric separation of the synthetic pyrethroid cis-bifenthrin (BF) was developed in this work. CD-MEKC was the CE mode employed for this purpose. The influence of several experimental parameters such as temperature, voltage, type and concentration of surfactant (chiral and achiral) and CD was investigated. The use of the bile salt sodium cholate at a concentration of 100 mM in the presence of 20 mM heptakis (2,3,6-tri-O-methyl)-beta-CD enabled the separation of cis-BF enantiomers in less than 10 min and with a resolution of 2.8. The analytical characteristics of the developed methodology were evaluated allowing its application to the quantitation of cis-BF in a polyvalent commercial insecticide formulation.

摘要

本工作开发了第一种能够对合成拟除虫菊酯顺式联苯菊酯（BF）进行对映体拆分的 CE 方法。为此目的采用了 CD-MEKC 作为 CE 模式。考察了几种实验参数的影响，例如温度、电压、表面活性剂（手性和非手性）和 CD 的类型和浓度。在存在 20mM 七（2,3,6-三-O-甲基）-β-CD 的情况下，使用浓度为 100mM 的胆酸钠能够在不到 10 分钟内实现顺式 BF 对映体的分离，并且分辨率为 2.8。评估了所开发方法的分析特性，允许将其应用于多价商业杀虫剂制剂中顺式 BF 的定量。