6 alpha,7 alpha-cyclopropane derivatives of androst-4-ene: a novel class of competitive aromatase inhibitors.
作者信息
Numazawa M, Mutsumi A
机构信息
Tohoku College of Pharmacy, Sendai, Japan.
出版信息
Biochem Biophys Res Commun. 1991 May 31;177(1):401-6. doi: 10.1016/0006-291x(91)91997-q.
PMID:2043124
Abstract
6 alpha,7 alpha-Cyclopropane steroids were found to be potent competitive inhibitors of human placental aromatase. 6 beta,7 beta-Dihydro-3'H-cyclopropa [6,7]-androst-4-en-17-one (4) has extremely high affinity for aromatase (Ki = 5 nM) but does not cause a time-dependent inactivation of the enzyme.
摘要
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