栝楼在正常和糖尿病大鼠中的水提取物的降血糖作用。
Hypoglycemic effect of aqueous extract of Trichosanthes dioica in normal and diabetic rats.
作者信息
Adiga Shalini, Bairy K L, Meharban A, Punita I S R
机构信息
Department of Pharmacology, Kasturba Medical College, Manipal - 576 104, India.
出版信息
Int J Diabetes Dev Ctries. 2010 Jan;30(1):38-42. doi: 10.4103/0973-3930.60011.
BACKGROUND
Trichosanthes dioica is used to treat diabetes mellitus, epilepsy, alopecia, and skin disease in folklore medicine. The leaf extract of the plant is used in diabetes mellitus but there have been no scientific studies reported.
AIMS
To study the effect of Trichosanthes dioica on serum glucose level in glucose loaded, normal and hyperglycemic rats.
SETTINGS
Kasturba Medical College, Manipal, Karnataka, India.
DESIGN
Experimental.
MATERIALS AND METHODS
The aqueous extract of leaves of Trichosanthes dioica are compared with glibeclamide for their influence on fasting blood sugar in glucose loaded, normoglycemic and streptozotocin induced (45 mg/kg ip) hyperglycemic rats.
STATISTICAL ANALYSIS
The data was analyzed by one way ANOVA followed by Scheffe's post hoc test.
RESULTS
In glucose loaded rats, normal rats and hyperglycemic rats the aqueous extract at both the doses (800 mg/kg/p.o and 1600 mg/kg/p.o) reduced blood glucose significantly when compared to control but it was not as effective as glibenclamide.
CONCLUSION
The aqueous extract of Trichosanthes dioica has antihyperglycemic action.
背景
在民间医学中，栝楼用于治疗糖尿病、癫痫、脱发和皮肤病。该植物的叶提取物用于治疗糖尿病，但尚无科学研究报道。
目的
研究栝楼对葡萄糖负荷、正常及高血糖大鼠血清葡萄糖水平的影响。
地点
印度卡纳塔克邦马尼帕尔市卡斯图尔巴医学院。
设计
实验性研究。
材料与方法
比较栝楼叶水提取物与格列本脲对葡萄糖负荷、血糖正常及链脲佐菌素诱导（腹腔注射45 mg/kg）的高血糖大鼠空腹血糖的影响。
统计分析
数据采用单因素方差分析，随后进行谢费尔事后检验。
结果
在葡萄糖负荷大鼠、正常大鼠和高血糖大鼠中，与对照组相比，两种剂量（800 mg/kg口服和1600 mg/kg口服）的水提取物均能显著降低血糖，但效果不如格列本脲。
结论
栝楼叶水提取物具有降血糖作用。
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